Value of undifferentiated connective tissue dysplasia in the development of female infertility

Objective: to Study the impact of undifferentiated connective tissue dysplasia (CTD) on female reproduction function. Setting: Department of Obstetrics and Gynecology, Stavropol State Medical Academy. Subjects: 157 patients with chronic genital inflammatory diseases (CGID) were divided into 2 groups: 1) 84 (53.5%) patients with CTD and 2) 73 (46.5%) patients without CTD. Methods: detection of external manifestations of CTD, echocardiography, rheography, small pelvic ultrasound study, hormonal profile determination, immunological study, selective salpingography. Results: the external manifestations of CTD and autonomic dysfunction were more frequently encountered in Group 1 patients. Mitral valve prolapse was the most common (97.6%) echocardiographic sign of CTD. Infertility was present in 49 (58.3%) patients in Group I and in 18 (24.7%) in Group 2. Hypokinetic circulation was identified in 27 (67.5%) patients in Group I and only in II (27.5%) in Group 2. The tuboperitoneal factor was a cause of infertility irrespective of the presence or absence of CTD. The basic parameters of cellular and humoral immunity did not differ from the normal values in Group 2 women. When infertility had occurred irrespective of the presence or absence of CTD, there was significant immunological dysfunction as a reduction in the count of total lymphocytes due to CD3, CD4, CD8, CD16, and CD25 lymphocytes and in the levels of IgA and IgM. When infertility had occurred after CGID, the decrease in the count of CD4 and CD25 lymphocytes was more pronounced in patients with CTD than in those without CTD. Conclusion: connective tissue dysplasia plays a certain part in the development of female infertility, namely its tuboperitoneal type.