IMPACT OF GENERAL OR SPINAL ANESTHESIA ON LIPID PEROXIDATION AND ANTIOXIDANT SYSTEM IN PATIENTS WITH ENDOMETRIOSIS

Objective. To study the impact of general and spinal anesthesia on lipid peroxidation (LPO) and antioxidant system (AOS) in patients with endometriosis and the perspectives of using the antioxidant and antihypoxant cytoflavin as a component of anesthesia during surgical interventions. Subjects and methods. One hundred and four patients aged 34 to 50 years with adenomyosis complicated by significant pain syndrome were examined. They underwent elective extrirpation of the uterus without its appendages by laparotomic access. According to the mode of anesthesia, the patients were divided into 2 groups; each group was classified into subgroups A (non-receiving antioxidant therapy) and B (receiving this therapy). Central and peripheral hemodynamic parameters, autonomic nervous system tone, and LPO (the content of malondialdehyde in plasma and erythrocyte hemolysates, amount of extracorpuscular hemoglobin, antioxidant activity of ceruloplasmin, activity of catalase in erythrocyte hemolysates and plasma) and AOS were studied. Results. Analysis of LPO and AOS processes showed that all patients in Subgroups 1A and 2A had initially imbalance of the antioxidant and prooxidant systems with a predominance of the activity of peroxidation processes. These processes were most pronounced in Subgroup 1A (total intravenous anesthesia). In the cytoflavin preadministration subgroups (1B and 2B), the levels of pro- and antioxidant enzymes were significantly higher than those in donors, but lower than those in Subgroups 1A and 2A. Conclusion. The use of cytoflavin as a component of anesthetic aid increases adaptation in endometriosis patients to surgical stress.

general and spinal anesthesia, endometriosis, cytoflavin, lipid peroxidation, antioxidants