Molecular genetic predictors of uterine inertia
- Авторлар: Kan N.E.1, Donnikov A.E.1, Tyutyunnik V.L.1, Kesova M.I.1, Demura T.A.1
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Мекемелер:
- Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
- Шығарылым: № 8 (2014)
- Беттер: 27-32
- Бөлім: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247232
- ID: 247232
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Аннотация
Objective. To study the relationship of myometrial morphological and immunohistochemical characteristics in parturients with uterine inertia and to identify molecular genetic predictors. Subject and methods. The study enrolled 112 patients who had delivered via cesarean section and were divided into 2 groups: 1) 49 patients with uterine inertia (a study group) and 2) 63 without this condition (a comparison group). Morphological and immunohistochemical examinations were made; gene polymorphisms were studied by a modified kissing probe technique. Results. Myometrial connective tissue disorganization was shown to be a morphological substrate of uterine inertia. There were also changes in the level of extracellular matrix proteins as the increased expression of collagen types III and IV in the myometrium and a relationship between the carriage of the T allele in LAMC gene polymorphism in uterine inertia. Conclusion. Morphological and immunohistochemical examinations have established that connective tissue disorganization with an impaired ratio of a number of structural proteins that are responsible for the architectonics of the extracellular matrix is a basis for the development of uterine inertia. The found relationships between the gene polymorphisms allow the use of genetic markers as noninvasive predictors for the formation of a risk group and for the possible prediction of uterine inertia.
Негізгі сөздер
Толық мәтін
Авторлар туралы
Natalya Kan
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: n_kan@oparina4.ru
doctor of medicine, the head
Andrey Donnikov
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: a_donnikov@oparina4.ru
PhD, senior scientific researcher laboratory of molecular genetics
Victor Tyutyunnik
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: tioutiounnik@mail.ru
doctor of medicine, the head of the obstetric observation department
Marina Kesova
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: m_kesova@oparina4.ru
PhD, MD, senior research scientist of the obstetric observation department
Tatiana Demura
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: t_demura@oparina4.ru
PhD, MD, senior research scientist of the 1st department for pathological anatomy
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