EXPERIMENTAL RATIONALE FOR THE ENDOTHELIAL PROTECTIVE EFFECT OF INTRAVENOUS IMMUNOGLOBULINS IN OBSTETRIC DISEASE


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Objective. To evaluate the cytoprotective effect of intravenous immunoglobulins (IVIGs) against endothelial cells. Subjects and methods. The cytotoxic effects of the sera obtained from 45 pregnant women against the endothelial cells treated with IVIGs were investigated using culture, an enzyme immunoassay, and flow cytometry. Results. After treatment of endothelial cells with IVIGs, there was a reduction in the cytotoxic effect of the sera obtained from the women with recurrent miscarriage against endothelial cells. Conclusion. IVIGs are effective cytoprotectors that are able to prevent abnormalities associated with endothelial damage and dysfunction.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Sergey Chepanov

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology

Email: chepanovsv@gmail.com
laboratory doctor, laboratory of immunology Saint Petersburg 199034, Mendeleyevskaya line 3, Russia

Dmitry Sokolov

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology

Email: falcojugger@yandex.ru
Doctor of biological sciences, leading researcher Saint Petersburg 199034, Mendeleyevskaya line 3, Russia

Tatiana Shlachtenko

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology

Email: tatnicshl@mail.ru
MD, Senior Researcher, Laboratory of Immunology Saint Petersburg 199034, Mendeleyevskaya line 3, Russia

Roman Kapustin

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology

Email: kapustin.Roman@gmail.com
MD, Obstetrician gynecologist Saint Petersburg 199034, Mendeleyevskaya line 3, Russia

Larisa Okorokova

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology

Email: larisaok123@gmail.com
researcher of the laboratory of immunology Saint Petersburg 199034, Mendeleyevskaya line 3, Russia

Ksenia Belyakova

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology

Email: kseniyabelyakova129@gmail.com
researcher of the laboratory of immunology Saint Petersburg 199034, Mendeleyevskaya line 3, Russia

Sergey Selkov

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology

Email: selkovsa@mail.ru
Doctor of medical sciences, head of the laboratory of immunology Saint Petersburg 199034, Mendeleyevskaya line 3, Russia

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