GENETIC PREDISPOSITION TO SEVERE OVARIAN HYPERSTIMULATION SYNDROME IN AN IVF PROGRAM IN A PATIENT WITH A NORMAL OVARIAN RESPONSE: A CLINICAL CASE


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Background. The prediction of a risk for ovarian hyperstimulation syndrome (OHSS) is relevant, as in spite of the assessment of clinical and laboratory indicators (age, body mass index (BMI), baseline follicle-stimulating hormone levels; anti-Müllerian hormone, number of antral follicles) and the implementation of early and late prevention measures, some patients develop OHSS, which presumes that genetic factors are involved in its development. Description. The paper describes a clinical case of severe OHSS in a patient with a normal ovarian response and shows that the development of this complication is associated with the OHSS risk genotypes detected during a pilot study. Conclusion. The clinical and laboratory markers used in routine practice to assess the risk of OHSS are inadequately objective and require confirmation by more specific methods. The determination of the genotypes of an OHSS risk is able to complement a panel of conventional procedures for predicting an ovarian response. Genetic testing is a highly specific procedure that can individually select an optimal ovarian stimulation protocol and minimize the risks associated with the development of OHSS.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Daria Strelchenko

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: da_strelchenko@mail.ru
graduate student Moscow 117997, Ac. Oparina str. 4, Russia

Svetlana Perminova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: perisvet@list.ru
MD, Leading Researcher of the 1st gynecological department Moscow 117997, Ac. Oparina str. 4, Russia

Andrey Donnikov

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia; OOO “DNA Technology Research-and-Production Firm”

Email: a_donnikov@oparina4.ru
PhD, senior staff scientist of laboratory of molecular genetic methods Moscow 117997, Ac. Oparina str. 4, Russia

Elena Saveleva

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: elena-galliamova@rambler.ru
graduate student Moscow 117997, Ac. Oparina str. 4, Russia

Әдебиет тізімі

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