A scientifically based system for predicting preeclampsia


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Objective. To develop and substantiate a predictive system for the management of pregnant women with risk factors of preeclampsia. Subjects and methods. A prospective cohort study was conducted in 150 pregnant women at risk for preeclampsia. Of them, there were 42 patients who subsequently developed preeclampsia (18 had early preeclampsia, 24 had late preeclampsia), 108 had no preeclampsia. A multivariate comparative analysis of anamnestic, clinical, and functional characteristics was carried out in pregnant women who subsequently developed preeclampsia. The time course of changes in the biomarkers of endothelial, placental dysfunction and impaired blood-brain barrier (BBB) permeability, such as TNF-α, VCAM, ICAM, VEGF, PIGF, sFlt-1, NSE, and GFAP, were traced. Results. A model was developed and scientifically substantiated to determine the likelihood of preeclampsia in risk-group pregnant women, which encompassed the assessment of anamnestic characteristics, uterine artery blood flow, daily changes in daily blood pressures, and alterations in the biomarkers of endothelial, placental dysfunction, and impaired BBB permeability. Conclusion. The pathophysiological changes preceding the clinical manifestation of preeclampsia permit prediction of its development just from the end of the first trimester of pregnancy.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Iraida Sidorova

I.M. Sechenov First Moscow State Medical University

MD, Professor, RAS Corresponding Member, Honoured Scientist of the Russian Federation; Therapeutic Faculty, Department of Obstetrics and Gynaecology № 1

Natalya Nikitina

I.M. Sechenov First Moscow State Medical University

Email: natnikitina@list.ru
Candidate of Medical Sciences, Associate Professor of the Chair of Obstetrics and Gynaecology № 1; Therapeutic Faculty, Chair of Obstetrics and Gynaecology № 1.

Әдебиет тізімі

  1. World Health Organization. WHO Recommendations for prevention and treatment of pre-eclampsia and eclampsia. Geneva; 2011. http://www.ncbi.nlm.nih. gov/books/NBK140561/?report= reader#!po= 16.6667.
  2. Стародубов В.И., Суханова Л.П. Репродуктивные проблемы демографического развития России. М.: Менеджер здравоохранения; 2012. 320с. [Starodubov V.I., Sukhanova L.P. Reproductive problems of Russia’s demographic development. Moscow: Manager of Health; 2012. 320p. (in Russian)]
  3. Филиппов О.С., Гусева Е.В., Сидорова И.С., Никитина Н.А. Материнская смертность в Российской Федерации: анализ официальных данных и результаты конфиденциального аудита в 2013 году. Методическое письмо Министерства здравоохранения Российской Федерации № 15-4/10/2750 9 от 02.10.2014. 91с. [Filippov O.S., Guseva E.V., Sidorova I.S., Nikitina N.A. Maternal mortality in the Russian Federation: analysis of official data and the results of confidential audit in 2013. Methodical letter of the Ministry of Health of the Russian Federation No. 15-4/10/2-7509 of 02.10.2014. 91p. (in Russian)]
  4. Филиппов О.С., Гусева Е.В., Сидорова И.С., Никитина Н.А. Результаты конфиденциального аудита материнской смертности в Российской Федерации в 2014 году. Методическое письмо Министерства здравоохранения Российской Федерации № 15-4/10/2-5993 от 09.10.2015. 50 с. [Filippov O.S., Guseva E.V., Sidorova I.S., Nikitina N.A. Results of confidential audit of maternal mortality in the Russian Federation in 2014. Methodical letter of the Ministry of Health of the Russian Federation No. 15-4/10/2-5993 of 09.10.2015. 50p. (in Russian)]
  5. Милованов А.П. Патология системы мать-плацента-плод. М.: Медицина; 1999. 44 с. [Milovanov A.P. Pathology of the mother-placenta-fetus system. Moscow: Medicine; 1999. 44 p. (in Russian)]
  6. Brosens I., Pijnenborg R., Vercruysse L., Romero R. The „Great Obstetrical Syndromes” are associated with disorders of deep placentation. Am. J. Obstet. Gynecol. 2011; 204(3): 193-201.
  7. Roberts J.M. Pathophysiology of ischemic placental disease. Semin. Perinatol. 2014; 38(3): 139-45.
  8. Ball E., Bulmer J.N., Ayis S., Lyall E., Robson S.C. Late sporadic miscarriage is associated with abnormalities in spiral artery transformation and trophoblast invasion. J Pathol. 2006; 208(4): 535-42.
  9. Kim Y.M., Bujold E., Chaiworapongsa T., Gomez R., Yoon B.H., Thaler H.T. et al. Failure of physiologic transformation of the spiral arteries in patients with preterm labor and intact membranes. Am. J. Obstet. Gynecol. 2003; 189(4): 1063-9.
  10. Kim Y.M., Chaiworapongsa T., Gomez R., Bujold E., Yoon B.H., Rotmensch S. et al. Failure of physiologic transformation of the spiral arteries in the placental bed in preterm premature rupture of membranes. Am. J. Obstet. Gynecol. 2002; 187(5): 1137-42.
  11. Urato A.C., Norwitz E.R. A guide towards pre-pregnancy management of defective implantation and placentation Best Pract. Res. Clin. Obstet. Gynaecol. 2011; 25(3): 367-87.
  12. Anderson U.D., Olsson M.G., Kristensen K.H., Akerström B., Hansson S.R. Biochemical markers to predict preeclampsia. Placenta. 2012; 33(Suppl.): S42-7.
  13. Lamarca B. Endothelial dysfunction. An important mediator in the pathophysiology of hypertension during pre-eclampsia. Minerva Ginecol. 2012; 64(4): 309-20.
  14. Young B.C., Levine R.J., Karumanchi S.A. Pathogenesis of preeclampsia. Annu. Rev. Pathol. 2010; 5: 173-92.
  15. Чазова И.Е., Ратова Л.Г., Бойцов С.А., Небиеридзе Д.В. (рабочая группа). Всероссийское медицинское общество по артериальной гипертонии (РМОАГ), Всероссийское научное общество кардиологов (ВНОК). Диагностика и лечение артериальной гипертензии. Российские рекомендации (четвертый пересмотр). Системные гипертензии. 2010; 3: 5-26. [Chazova I.E., Ratova L.G., Boytsov S.A., Nebieridze D.V. (working group). All-Russian Medical Society for Arterial Hypertension (RIOH), All-Russian Scientific Society of Cardiology (VNOK). Diagnosis and treatment of hypertension. Russian recommendations (fourth revision). Sistemnyye gipertenzii. 2010; 3: 5-26. (in Russian)]
  16. Краснопольский В.И., Титченко Л.И., Туманова В.А., Петрухин В.А., Чечнева М.А., Пырсикова Ж.Ю. Возможности использования трехмерной допплерометрии для исследования внутриплацентарного кровотока у беременных с высоким риском развития перинатальной патологии. Российский вестник акушера-гинеколога. 2003; 3(3): 5-9. [Krasnopolsky V.I., Titchenko L.I., Tumanova V.A., Petrukhin V.A., Chechneva M.A., Pirsikova Zh.Yu. Possibilities of using 3D dopplerometry for the study of intraplacental blood flow in pregnant women with a high risk of perinatal pathology. Rossiyskiy vestnik akushera-ginekologa. 2003; 3 (3): 5-9. (in Russian)]
  17. Hafner E., Metzenbauer M., Höfinger D., Stonek E., Schuchter K., Waldhör T., Philipp K. Comparison between three-dimensional placental volume at 12 weeks and uterine artery impedance/notching at 22 weeks in screening for pregnancy-induced hypertension, pre-eclampsia and fetal growth restriction in a low-risk population. Ultrasound Obstet. Gynecol. 2006; 27(6): 652-7.
  18. Odibo A.O., Zhong Y., Longtine M., Tuuli M., Odibo L., Cahill A.G. et al. Firsttrimester serum analytes, biophysical tests and the association with pathological morphometry in the placenta of pregnancies with preeclampsia and fetal growth restriction. Placenta. 2011; 32(4): 333-8.

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML
Жүктеу

© Bionika Media, 2017

Осы сайт cookie-файлдарды пайдаланады

Біздің сайтты пайдалануды жалғастыра отырып, сіз сайттың дұрыс жұмыс істеуін қамтамасыз ететін cookie файлдарын өңдеуге келісім бересіз.< / br>< / br>cookie файлдары туралы< / a>