Molecular hydrogen and reproduction


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

The paper analyzes the data available in the current literature on the role of molecular hydrogen in the combination therapy of subfertility and infertility. It gives data on the possible mechanisms of antioxidant action of molecular hydrogen, as well as those on the methods for its use, which are available in clinical practice. There are also results of individual studies demonstrating the efficacy of molecular hydrogen in the treatment of some forms of infertility. The results of ongoing investigations confirm that molecular hydrogen is one of the promising antioxidant drugs used in clinical practice. To create algorithms for the individual preparation of patients for pregnancy, it is necessary to conduct further studies of sufficient power.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Anastasia Syrkasheva

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia

Email: a_syrkasheva@oparina4.ru
M.D., Ph.D., Senior Researcher of the IVF Department

Nataliya Dolgushina

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia

Email: n_dolgushina@oparina4.ru
M.D., Ph.D., M.P.H., Head of R&D Department

Әдебиет тізімі

  1. Practice Committee of tAmerican Society for Reproductive Medicine. Definitions of infertility and recurrent pregnancy loss. Fertil Steril. 2008; 90(5, Suppl.): S60.
  2. Казанцева Е., Долгушина Н.В., Донников А.Е., Беднягин Л.А., Баранова Е.Е., Терешков П.П. Влияние пренатальной экспозиции бенз(а)пирена, стирола и формальдегида на массу тела при рождении в зависимости от полиморфизмов генов системы детоксикации. Акушерство и гинекология. 2016; 7: 68-78. http://dx.doi.org/10.18565/aig.2016.7.68-78
  3. Калинина Е.В., Чернов Н.Н., Новичкова М.Д. Роль глутатиона, глутатионтрансферазы и глутаредоксина в регуляции редокс-зависимых процессов. Успехи биологической химии. 2014; 54: 299-348.
  4. Agarwal A., Aponte-Mellado A., Premkumar B.J., Shaman A., Gupta S. The effects of oxidative stress on female reproduction : a review. Reprod. Biol. Endocrinol. 2012; 10: 49.
  5. Sedha S., Kumar S., Shukla S. Role of oxidative stress in male reproductive dysfunctions with reference to phthalate compounds. Urol. J. 2015; 12(5): 2304-16.
  6. Mg S., Brown J., Clarke J., Rj H. Antioxidants for female subfertility ( Review ). Cochrane Database Syst. Rev. 2013; (8): CD007807.
  7. Finkel T., Holbrook N. Oxidants, oxidative stress and the biology of ageing. Nature. 2000; 408(6809): 239-47.
  8. Ohsawa I., Ishikawa M., Takahashi K., Watanabe M., Nishimaki K., Yamagata K. et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat. Med. 2007; 13(6): 688-94.
  9. Dixon B.J., Tang J., Zhang J.H. The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance. Med. Gas. Res. India. 2013; 3(1): 10.
  10. Ohta S. Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine. Pharmacol. Ther. 2014; 144(1): 1-11.
  11. Bjelakovic G., Nikolova D., Gluud L., Simonetti R., Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst. Rev. 2012; (3): CD007176.
  12. Smith R., Murphy M. Mitochondria-targeted antioxidants as therapies. Discov. Med. 2011; 11(57): 106-14.
  13. Kimura H. Hydrogen sulfide: from brain to gut. Antioxid. Redox Signal. 2010; 12(9): 1111-23.
  14. Guo W., Kan J., Cheng Z., Chen J., Shen Y., Xu J. et al. Hydrogen sulfide as an endogenous modulator in mitochondria and mitochondria dysfunction. Oxid. Med. Cell. Longev. 2012; 2012: 878052.
  15. Polhemus D., Lefer D. Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease. Circ. Res. 2015; 114(4): 730-7.
  16. Sun Q., Cai J., Liu S., Liu Y., Xu W., Tao H. et al. Hydrogen-rich saline provides protection against hyperoxic lung injury. J. Surg. Res. 2011; 165(1): 43-9.
  17. Kubota M., Shimmura S., Kubota S., Miyashita H., Kato N., Noda K. et al. Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model. Invest. Ophthalmol. Vis. Sci. 2011; 52(1): 427-33.
  18. Nakata K., Yamashita N., Noda Y., Ohsawa I. Stimulation of human damaged sperm motility with hydrogen molecule. Med. Gas. Res. India. 2015; 5(1): 2.
  19. Wang J., Wang W., Li S., Han Y., Zhang P., Meng G. et al. Hydrogen sulfide as a potential target in preventing spermatogenic failure and testicular dysfunction. Antioxid. Redox Signal. 2018; 28(16): 1447-62.
  20. He X., Wang S.Y., Yin C.H., Wang T., Jia C.W., Ma Y.M. Hydrogen-rich water exerting a protective effect on ovarian reserve function in a mouse model of immune premature ovarian failure induced by zona pellucida 3. Chin. Med. J. (Engl.). 2016; 129(19): 2331-7.

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML

Осы сайт cookie-файлдарды пайдаланады

Біздің сайтты пайдалануды жалғастыра отырып, сіз сайттың дұрыс жұмыс істеуін қамтамасыз ететін cookie файлдарын өңдеуге келісім бересіз.< / br>< / br>cookie файлдары туралы< / a>