Characteristics of autoantibodies associated with recurrent pregnancy loss


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Objective. To investigate the spectrum of autoantibodies and their correlation with markers of endothelial damage in women with recurrent pregnancy loss. Material and methods. The study comprised 561 women of reproductive age, who were tested for peripheral blood serum levels of autoantibodies and markers of endothelial dysfunction. Results. APS-associated autoantibodies were found in 31.7% of patients with recurrent pregnancy loss. Among the identified autoantibodies, the most prevalent were lupus anticoagulant and antibodies to beta-2glycoprotein-I. Peripheral blood levels of endothelial damage markers in women with recurrent pregnancy loss were higher than in women with normal pregnancies. Conclusion. Women with recurrent pregnancy loss have high detection rates of APS-associated autoantibodies. Vascular endothelial cell dysfunction mediated by APS-associated autoantibodies increases the risk of thrombosis.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Sergey Chepanov

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology

Email: chepanovsv@gmail.com
PhD at the Clinical Laboratory Diagnostics, Laboratory of Clinical Immunology

Marina Krivonos

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology

Email: mmirashvili@ya.ru
obstetrician-gynecologist

Olga Arzhanova

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology; Saint Petersburg State University

Email: arjanova_olga@mail.ru
MD, professor, honored physician of the RF, head of the Obstetric Department of Pathology of Pregnancy №ll; professor at the Department of Obstetrics, Gynecology, and Reproductology

Tatiana Shladitenko

Center for Diagnosis, Prevention and Treatment of Recurrent Pregnancy Loss at Maternity Hospital No. 1, St. Petersburg

Email: tatnicshl@mail.ru
PhD, immunologist

Navruz Saidov

Research Institute of Obstetrics, Gynecology and Perinatology

Email: navruz.saidov.l983@mail.ru
clinical pathologist, researcher at the Laboratory of Biochemistry and Immunology

Ekaterina Kornyushina

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology

Email: hapacheva@yandex.ru
obstetrician-gynecologist at the Obstetric Department of Pathology of Pregnancy, senior Researcher

Kirill Chudotvorov

First Pavlov SMU of St. Petersburg

Email: chudotvorovkn@gmail.com
IV year student

Vladislav Sedihin

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology

Email: sedihin@mail.ru
clinical pathologist at the Biochemistry Laboratory

Sergey Selkov

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology

Email: selkovsa@mail.ru
MD, professor, the honored scientist of the RF, head of the Department of Immunology and Intercellular Interactions

Әдебиет тізімі

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