Experience with different cholecalciferol dosing regimens to achieve adequate levels in patients with reproductive dysfunction

Objective. To study the time course of changes in the serum level of 25(OH)D in the use of different doses of cholecalciferol as chewable tablets dispersed in the mouth (the dietary supplement (DS) Ultra-D Vitamin D3). Subjects and methods. A total of 125 reproductive-aged patients took cholecalciferol as chewable tablets dispersed in the mouth (DS Ultra-D Vitamin D3). Groups 1, 2, and 3 received DS Ultra-D Vitamin D3 in daily doses of 4.000, 5.000, and 6.000 IU, respectively. The use duration was 8 weeks. 25(OH)D was determined by a chemiluminescent microparticle immunoassay. Results. When the chewable tablets were used in a daily dose of 4.000 IU, the vitamin D levels above 30 ng/ml were achieved in 100% of patients; M ± s 45.75 ± 7.84ng/ml; the dynamics was 123 А%. When the chewable tablets were given in daily dose of 5.000 and 6.000 IU, the vitamin D level above 30 ng/ml was achieved in 93.5 and 96.8% of the patients, respectively; its mean concentrations for the group were 36.86 ± 6.03 and 40.64 ± 4.95ng/ml, respectively; the dynamics was 103 and 116.5 A%. Conclusion. The 8-week use of cholecalciferol at a daily dose of 4,000IU as chewable tablets dispersed in the mouth is sufficient to achieve an adequate vitamin D level.

vitamin D, adequate level, dose, chewable tablets