Preimplantation genetic testing of embryos in assisted reproductive technology programs in patients with external genital endometriosis


Дәйексөз келтіру

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Аннотация

According to published data, external genital endometriosis (EGE) leads to decline of oocyte quality/quantity and the effectiveness of ART programs. In patients with EGE, oocytes may be chromosomally unstable. This may affect the incidence of embryonic aneuploidy. Aim: To assess the incidence of aneuploid embryos in women with EGE versus women of appropriate age without EGE, who underwent fertility treatment with ART programs. Materials and methods: The group of women with EGE included 113 women, and the control group included 211 women. The group of women with endometriosis consisted of 113 patients, the control group comprised 211 women. Each group was divided into three subgroups depending on the age (<35 years, 35-37years, >37 years). To assess whether an embryo was aneuploid, high-resolution next-generation sequencing (NGS) was performed after trophectoderm. Results: There were no statistically significant differences in embryonic parameters, aneuploidy rates in embryos, and the outcomes of ART programs in patients with EGE versus the control when comparing the subgroups of appropriate age. Conclusion: It was shown, that there is no obvious impact of EGE on the effectiveness of ART programs after embryo transfer. However, a potential effect of endometriosis on the number of removed MII oocytes, as well as the rate of aneuploid embryos cannot be ignored. For detailed study of the effect of EGE on the incidence of aneuploidy further prospective research is necessary.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Elena Kulakova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: e_kulakova@oparina4.ru
PhD, Senior Researcher, Professor BV. Leonov Department of IVF

Oksana Nepsha

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: o_nepsha@oparina4.ru
PhD. (Biol. Sci.), Researcher at the BV. Leonov Department of Assisted Technologies for the Treatment of Infertility

Alexey Ekimov

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: a_ekimov@oparina4.ru
doctor-laboratory geneticist, Head of the Group of preimplantation genetic screening of the Laboratory of Molecular Genetic Methods

Yulia Drapkina

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: yu_drapkina@oparina4.ru
PhD, researcher, Professor BV. Leonov Department of IVF

Natalya Makarova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: np_makarova@oparina4.ru
Dr. Bio. Sci., Leading Researcher, Professor BV. Leonov Department of IVF

Luiza Ibragimova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: ibragimova_luisa0693@mail.ru
postgraduate student, Professor BV. Leonov Department of IVF

Anastasia Sysoeva

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: sysoeva.a.p@gmail.com
embryologist, Professor B.V. Leonov Department of IVF

Elena Kalinina

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: e_kalinina@oparina4.ru
Dr. Med. Sci., Professor, Head of the BV. Leonov Department of Assisted Technologies for the Treatment of Infertility

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