Clinical characteristics and embryological parameters in IVF programs for women with unexplained infertility


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Abstract

Objective: Analysis of clinical characteristics and embryological parameters in IVF programs for women with infertility of unclear genesis versus the patients with tuboperitoneal infertility. Materials and methods: The clinical characteristics of women with infertility of unclear genesis versus the patients with tuboperitoneal infertility were analyzed retrospectively and prospectively. The study group comprised 93 women, and the control group consisted of 45 patients. Embryological parameters in fertility treatment programs were compared between 108 women with infertility of unclear genesis and 49 women with tuboperitoneal infertility. The ovarian stimulation protocols were comparable between the groups of patients. Severe deviations in spermogram parameters and possible infertility factors in the partners were excluded. Results: Significant differences were found between the groups in anamnestic, clinical, laboratory, and instrumental characteristics including women's age, mean age of their partners, women's body weight and body mass index, hereditary anamnesis, chronic diseases, previous pelvic and cervical surgery, and the infection in the pelvic organs. Statistically significant differences were found between the age at menarche, duration of menstruation and painful periods, and the data of reproductive history: the duration of unprotected sexual activity, time of establishing the diagnosis, duration of treatment before admission to IVF clinic, the use of other infertility treatment options before IVF treatment, the number of intrauterine inseminations and IVF attempts in anamnesis. The blastulation rate was considered to be the endpoint in IVF treatmen, and it was significantly lower in the group of women with infertility of unclear genesis. Conclusion: Clinical characteristics and embryological parameters of IVF treatment programs for women with infertility of unclear genesis were determined. A "clinical portrait" of women with infertility of unclear genesis was described and specific features of infertility were identified versus the women with tuboperitoneal infertility. The low blastulation rate was noted in IVF programs for women with infertility of unclear genesis. This may be an indirect sign of impaired embryonic development at early stages, and, therefore, can be an indication for earlier IVF treatment in order to achieve pregnancy.

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About the authors

Evgeniya V. Kirakosyan

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University); Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: evgeniya.kirakosyan@mail.ru
PhD. student, Department of Obstetrics, Gynecology, Perinatology and Reproductology

Tatyana A. Nazarenko

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: t_nazarenko@oparina4.ru
Dr. Med. Sci., Professor, Director of the Institute of Reproductive Medicine

Alexey V. Bachurin

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: a_bachurin@oparina4.ru
Ph.D., Head of the Laboratory of Clinical Embryology, Scientific and Clinical Department of ART named after F. Paulsen

Stanislav V. Pavlovich

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University); Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: s_pavlovich@oparina4.ru
PhD, Associate Professor, Scientific Secretary

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