Endometriosis comorbidity and its clinical significance

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Abstract

Comorbidity is one of the urgent interdisciplinary problems of modern medicine, including gynecology. From the standpoint of diagnosing endometriosis, the assessment of the comorbidity is one of the most effective and affordable methods of primary screening for this group of female patients. However, patient complaints, clinical presentations, and gynecological diseases are mainly evaluated in real clinical practice, while a somatic history is not fully assessed and sometimes completely ignored. Nevertheless, the relationship of endometriosis to a non-gynecological disease may be of great clinical significance. The modern Russian and foreign literature sources rather widely discuss the comorbidity of endometriosis with thyroid, cardiovascular, and fibrocystic diseases, and cancers. However, a wide range of concomitant non-gynecological diseases, which is, nevertheless, quite common and is of prognostic signif icance for the diagnosis of endometriosis, rema ins unaddressed. The review presents the data demonstrating the common etiology and pathogenesis of endometriosis with low body mass index (BMI), acne, migraine, and irritable bowel syndrome (IBS). The comorbidity of endometriosis with low BMI and acne has been insufficiently studied due to lack of a strong evidence base for this relationship. Nevertheless, these comorbidities are not only easy to diagnose at a primary outpatient visit, but they also have a sufficient degree of specificity to identify women at risk for the disease along with well-known disorders, such as migraine and IBS. Conclusion: Information about the comorbidity of endometriosis with both gynecological diseases and non-gynecological ones can serve as the basis for appropriate patient counseling at the initial examination stage. This will assist in reducing the time to diagnosis and in minimizing the use of invasive research methods.

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About the authors

Galina E. Chernukha

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: c-galinal@yandex.ru
Dr. Med. Sci., Professor, Chief Researcher, obstetrician-gynecologist at the Department of Gynecological Endocrinology

Veronika A. Pronina

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: ver22595@yandex.ru
obstetrician-gynecologist, PhD student

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