Association of polymorphic variants RS699517 and RS2790 of the maternal TYMS gene with newborn birthweight

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Objective: To investigate the associations between maternal folate cycle gene polymorphisms and newborn birthweight, as well as evaluate their functional effects.

Materials and methods: A molecular genetic study was conducted on five polymorphic gene loci involved in folic acid and methionine metabolism (rs699517 TYMS, rs2790 TYMS, rs1979277 SHMT1, rs1805087 MTR, and rs1801394 MTRR) using the genomic DNA of 317 pregnant women.

Results: The birthweight of newborns with different maternal genotypes for the loci studied showed slight changes, but no significant differences were observed (p>0.05): rs699517 TYMS (3449.63 vs. 3551.44 g), rs2790 TYMS (3441.82 vs. 3511.29 g), rs1979277 SHMT1 (3484.05 vs. 3527.66 g), rs1805087 MTR (3477.50 vs. 3522.08 g), rs1801394 MTRR (3464.74 vs. 3550.98 g). Among the haplotypes, the TA haplotype (rs699517-rs2790 TYMS) occurred at a frequency of 0.13 and showed a significant association with birthweight (β=0.14, p=0.02, pperm=0.03). However, the TG haplotype (frequency 0.17) and the CA haplotype (frequency 0.70) were not significantly associated with birthweight.

Conclusion: The TA haplotype rs699517–rs2790 of TYMS may be associated with higher birthweight.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Yuliya Reshetnikova

Belgorod National Research University

Email: resh_yul@mail.ru
ORCID iD: 0009-0004-6123-4086

PhD Student at the Department of Biomedical Disciplines

Ресей, Belgorod

Irina Ponomarenko

Belgorod National Research University

Email: ponomarenko_i@bsu.edu.ru
ORCID iD: 0000-0002-5652-0166

Dr. Med. Sci., Professor at the Department of Biomedical Disciplines

Ресей, Belgorod

Mikhail Churnosov

Belgorod National Research University

Email: churnosov@bsu.edu.ru
ORCID iD: 0000-0003-1254-6134

Dr. Med. Sci., Professor, Head of the Department of Biomedical Disciplines

Ресей, Belgorod

Evgeny Reshetnikov

Belgorod National Research University

Хат алмасуға жауапты Автор.
Email: reshetnikov@bsu.edu.ru
ORCID iD: 0000-0002-5429-6666

Dr. Bio. Sci., Professor at the Department of Biomedical Disciplines

Ресей, Belgorod

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