Endothelial functional activity in women of reproductive age and menopausal women with metabolic syndrome

Мұқаба

Дәйексөз келтіру

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Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Objective: This study aimed to investigate the functional state of the endothelium in patients with metabolic syndrome (MS) during the late reproductive age and early postmenopausal period.

Materials and methods: The study included 85 women with MS, of whom 35 patients (group 1) were of late reproductive age (mean age 44.3 (5.8) years) and 46 women (group 2) were of early postmenopausal age (mean age 51.5 (3.4) years). The control group consisted of 29 healthy women with a mean age of 41.4 (11.3) years. Biometric and metabolic parameters, lipid spectrum, follicle-stimulating hormone (FSH), and estradiol levels were measured. Laboratory markers of endothelial dysfunction (ED) including exfoliated endothelial cells (EEC), endothelin-1, vascular endothelial growth factor (VEGF), and von Willebrand factor activity were also assessed. The functional state of the endothelium was evaluated using local skin thermometry using a Microtest device (Russia).

Results: Laboratory signs of MS were more pronounced in postmenopausal patients in both groups. Hormonal status assessment revealed a significant increase in FSH and a decrease in estradiol levels in menopausal women with MS compared to menstruating patients with MS. The number of laboratory markers of ED in both subgroups of women with MS was significantly higher than that of the control group. Additionally, the activity of von Willebrand factor, which indicates thrombogenic potential and degree of endothelial damage, and the blood level of the vasoconstrictor endothelin-1 in patients with menopausal MS exceeded those in fertile women (p = 0.041 and p = 0.031, respectively).

Conclusion: Late reproductive age and early postmenopausal period in women with MS are accompanied by the development of dyslipidemia and significant changes in the vascular system, resulting in ED with increased levels of endothelin-1, EEC, VEGF, and von Willebrand factor activity, as well as impaired physiological vasodilation in response to local heating. As estrogen levels decrease, the severity of MS components and dyslipidemia increases, and ED progresses in the form of persistent vasoconstriction.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Tatyana Shevlyukova

Tyumen State Medical University, Ministry of Health of Russia

Email: tata21.01@mail.ru
ORCID iD: 0000-0002-7019-6630

Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology

Ресей, Tyumen

Irina Bulatova

Academician E.A. Wagner Perm State Medical University, Ministry of Health of Russia

Хат алмасуға жауапты Автор.
Email: bula.1977@mail.ru
ORCID iD: 0000-0002-7802-4796

Dr. Med. Sci., Head of the Department of Normal Physiology, Professor at the Department of Faculty Therapy No. 2, Occupational Pathology and Clinical Laboratory Diagnostics

Ресей, Perm

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