Plasma miRNA expression levels in women with preeclampsia and chronic arterial hypertension in the first trimester of pregnancy

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Дәйексөз келтіру

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Аннотация

Objective: This study aimed to investigate the expression of several miRNAs in the plasma of patients with chronic arterial hypertension (CAH) without preeclampsia and pregnant women with CAH-associated preeclampsia (CAP) during the first trimester of pregnancy.

Materials and methods: The study included 100 patients: Group 1 (n=58) comprised pregnant women with CAH without preeclampsia, and Group 2 (n=42) included women with CAP. The plasma expression levels of 11 miRNAs were assessed in these patients at 12–14 weeks of gestation using quantitative real-time polymerase chain reaction. Statistical analysis was conducted using the IBM SPSS Statistics software (version 26.0, USA).

Results: Women with CAP exhibited contrasting changes in the expression of five out of 11 plasma miRNAs compared to the group without CAP. The expression levels of miRNA-20a (p<0.001) and miRNA-181a (p<0.001) were significantly decreased in the CAP group. Conversely, the expression levels of miRNA-221 (p<0.001), miRNA-146a (p=0.02), and miRNA-210 (p=0.041) were higher in this group than in women who did not develop preeclampsia.

Conclusion: Statistically significant changes in the expression levels of several miRNAs associated with cardiovascular pathology and placental dysfunction were identified in the first trimester of pregnancy in patients with CAH and CAP.

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Авторлар туралы

Yurii Semenov

Ural Research Institute for Maternity and Child Care, Ministry of Health of the Russian Federation

Email: u-sirius@mail.ru
ORCID iD: 0000-0002-3268-7981

Dr. Med. Sci., Associate Professor, Director

Ресей, Yekaterinburg

Vladimir Antonov

South Ural State Medical University, Ministry of Health of the Russian Federation

Email: ant-vn@yandex.ru
ORCID iD: 0000-0002-3531-3491

Dr. Med. Sci., Associate Professor, Professor at the Therapy Department of the Institute of Continuing Professional Education

Ресей, Chelyabinsk

Evgeniia Azarenkova

Ural Research Institute for Maternity and Child Care, Ministry of Health of the Russian Federation

Хат алмасуға жауапты Автор.
Email: jennysplean@mail.ru
ORCID iD: 0000-0001-9656-350X

Head of the Educational and Methodological Department

Ресей, Yekaterinburg

Anna Chizhovskaya

Ural Research Institute for Maternity and Child Care, Ministry of Health of the Russian Federation

Email: ms.chizhovskaya@mail.ru
ORCID iD: 0000-0003-1574-1613

Deputy Director for Organizational and Methodological Work and Public Issues

Ресей, Yekaterinburg

Yuliya Veryaskina

Institute of Molecular and Cell Biology, Siberian Branch of the Russian Academy of Sciences

Email: microrna@inbox.ru
ORCID iD: 0000-0002-3799-9407

PhD, Researcher at the Laboratory of Molecular Genetics, Department of Chromosome Structure and Function

Ресей, Novosibirsk

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