A new perspective on uterine embryogenesis

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Дәйексөз келтіру

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Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Background: The embryonic development of the uterus and vagina has been studied through a systematic review of scientific literature, from the earliest published papers to the most recent studies. According to the theory proposed by Muller in 1830, the fallopian tubes, uterus, and vagina develop from fused paramesonephric ducts, while the mesonephric ducts are reduced in the female fetus.

Results: A comparative analysis of clinical variations of uterine abnormalities was conducted based on the results of the observations between 1996 and 2025. Some complex issues have been identified, namely, how to draw a distinction line between the uterus, which has a thick layer of myometrium and endometrial cavity, and the fallopian tubes and vagina during the fusion of symmetrical genital ducts. The origin of the normal endometrium is still unknown. The results of the review demonstrated the chronological stages of embryonic morphogenesis; relevant references to primary sources were provided.

Conclusion: A new theory of uterine embryogenesis has been formulated: the fallopian tubes and vagina develop from the mesonephric ducts, and the uterus is formed by the fusion of the mesonephric ducts with the gonadal ridges. The proposed new theory may be the key to understanding abnormalities in the development of the uterus, as well as major gynecological diseases such as myoma and endometriosis from embryonic polypotent cells.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Zograb Makiyan

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Хат алмасуға жауапты Автор.
Email: makiyan@mail.ru
ORCID iD: 0000-0002-0463-1913

Dr. Med. Sci., Leading Researcher at the Department of Operative Gynecology

Ресей, Moscow

Әдебиет тізімі

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1. JATS XML
Жүктеу
2. Fig. 1. Muller's theory

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3. Fig. 2. Histological examination, longitudinal frontal section of an embryo at Carnegie stage 13 [7]

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4. Fig. 3. Electron micrograph of a mouse embryo [3]

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5. Fig. 4. Histological examination, cross-section of a female embryo at Carnegie stage 22 [8]

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6. Fig. 5. Feulgen staining of the uterus of female rats after administration of GD 15 1.0 μgTCDD/kg shows the width of the interductal mesenchyme [9]

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7. Fig. 6. The uterine rudiment (in the yellow circle) is located in the area of ​​intersection of the fallopian tube, with the proper ovarian ligament and the round ligament. Own data

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8. Fig. 7. Histological examination of a functioning uterine rudiment with an endometrial cavity in a 20-year-old female patient with aplasia of the uterus and vagina, with complaints of abdominal pain [14]. Laparoscopy was performed, removal of uterine rudiments. The uterine rudiment is round in shape, measuring 35x25x40 mm, formed in the area of ​​​​the fusion of the fallopian tubes with the round ligaments and the proper ligaments of the ovaries. The endometrial cavity is oval in shape, measuring 8x5x6 mm, surrounded by circularly oriented myocytes, communicates only with the lumen of the orifice of the fallopian tube

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9. Fig. 8. Diagram of the embryonic development of the internal genital organs according to the female type. Primordial germ cells migrate from the hypoblEST to the area of ​​the gonadal cords.

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