OOCYTE DYSMORPHISMS IN IN VITRO FERTILIZATION CYCLES: A REVIEW OF LITERATURE


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Abstract

The quality of oocytes is one of the major factors limiting female fertility. The morphological and structural maturity of sex cells determines the further fate of an embryo and hence the chance of conception and birth of a healthy baby. The literature actively discusses an association between the quality of oocytes obtained after stimulation of functions and the unsuccessful outcomes of in vitro fertilization/intracytoplasmic sperm injection. Noninvasive selection of oocytes that can become fertile and develop further is an important problem whose solution may considerably enhance the efficiency of assisted reproductive technologies in the future. Oocyte structural abnormalities (dysmorphisms) are classified into two groups: cytoplasmic and extracytoplasmic. There is evidence that fertilization and further embryo development are particularly influenced by cytoplasmic dysmorphisms as their presence determines the cytoplasmic immaturity of a cell. At the same time, the risk factors of different oocyte dysmorphisms have not been identified. By taking into account contraversions in the study of different types of oocyte dysmorphisms and their impact on the outcomes of assisted reproductive technologies, it is necessary to investigate further this problem.

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About the authors

Anastasia Grigorievna GORSHKOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_gorshkova@oparina4.ru
MD, Postgraduate of the Department of assistive reproductive technology in the treatment of infertility

Nataliya Petrovna MAKAROVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: np_makarova@oparina4.ru
PhD, Researcher of the Department of assistive reproductive technology in the treatment of infertility

Nataliya Vitalievna DOLGUSHINA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_dolgushina@oparina4.ru
MD, PhD, MPH, Head of R&D Department

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