Biological role of lactic acid in the stability of the vaginal microecosystem


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Resumo

Lactic acid is the most important biological substrate in maintaining the optimum biological homeostasis of the vaginal microecosystem and femilex as vaginal suppositories containing 100 mg of lactic acid restores pH, promotes glycogen accumulation, and has microbicidal and immunomodulatory properties; the drug is used to treat hypo- and anacidic disorders in the vaginal environment.

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Sobre autores

E. Kira

N.I. Pirogov National Medical and Surgical Center

Email: profkira33@gmail.com
MD, professor, Chief Obstetrician & Gynecologist, Head of Department of Female Disease and Reproductive Health

O. Molchanov

S.M. Kirov Military Medical Academy, Ministry of Defense of Russia

Email: moleg700@mail.ru
MD, professor, Head of the Department of assisted reproductive technology

K. Semenova

N.I. Pirogov National Medical and Surgical Center

obstetrician-gynecologist, Women’s Health Clinic Nine, Saint Petersburg, graduate student of Department of Female Disease and Reproductive Health

Bibliografia

  1. Кира Е.Ф. Бактериальный вагиноз (клиника, диагностика, лечение): автореф. дис.. д-ра мед. наук. СПб.; 1995. 44 с. [Kira E.F. Bacterial vaginosis (clinic, diagnosis, treatment). Diss. SPb.; 1995. 44 p. (In Russian)]
  2. Кира Е.Ф. Бактериальный вагиноз. М.: МИА; 2012. 472 с. [Kira E.F. Bacterial vaginosis. M.: MIA; 2012. 472 p. (In Russian)]
  3. Молчанов О.Л. Биохимические и биологические свойства влагалищной жидкости у здоровых небеременных женщин в репродуктивном возрасте: автореф. дис.. д-ра мед. наук. СПб.; 2000. 30 с. [Molchanov О.L. Biochemical and biological properties of vaginal fluid in healthy non-pregnant women of reproductive age. Diss. SPb.; 2000. 30 p. (In Russian)]
  4. Берлев И.В. Состояние микроэкосистемы влагалища у беременных и ее роль при инфекционной патологии в акушерской практике: автореф. дис.. д-ра мед. наук. СПб.; 2001. 37 с. [Berlev I.V. Condition of vaginal microecosystem in pregnant women and its role by infection pathology in obstetric practice. Diss. SPb.; 2001. 37 p. (In Russian)]
  5. Boskeye E.R., Cone R.A., Whaley K.J., Moench T.R. Origins of vaginal acidity: high D/L lactate ratio is consistent with bacteria being the primary source. Hum. Reprod. 2001; 16(9): 1809-13.
  6. Liston W.G., Chisholm F.B. Leucorrhoea in pregnancy; a further study with special reference to the hydrogen ion concentration and lactic acid content of the vagina. J. Obstet. Gynaecol. Br. Emp. 1947; 54(5): 592-606.
  7. Roth S., Gmünder H., Dröge W. Regulation of intracellular glutathione levels and lymphocyte functions by lactate. Cell. Immunol. 1991; 136(1): 95-104.
  8. Sims C.J., Fujito D.T., Burholt D.R., Dadok J., Giles H.R., Wilkinson D.A. Quantification of human amniotic fluid constituents by high resolution proton nuclear magnetic resonance (NMR) spectroscopy. Prenat. Diagn. 1993; 13(6): 473-80.
  9. Gottfried E., Kunz-Schughart L.A., Ebner S., Mueller-Klieser W., Hoves S., Andreesen R. et al. Tumor-derived lactic acid modulates dendritic cell activation and antigen expression. Blood. 2006; 107(5): 2013-21.
  10. Zhou X., Bent S.J., Schneider M.G., Davis C.C., Islam M.R., Forney L.J. Characterization of vaginal microbial communities in adult healthy women using cultivation-independent methods. Microbiology. 2004; 150(Pt 8): 2565-73.
  11. Gorodeski G.I., Hopfer U., Liu C.C., Margles E. Estrogen acidifies vaginal pH by Up-regulation of proton secretion via the apical membrane of vaginal-ectocervical epithelial cells. Endocrinology. 2005; 146(2): 816-24.
  12. McCabe K., Mann M.D., Bowie M.D. D-lactate production and [14C]succinic acid uptake by adherent and nonadherent Escherichia coli. Infect. Immun. 1998; 66(3): 907-11.
  13. Boskey E.R., Telsch K.M., Whaley K.J., Moench T.R., Cone R.A. Acid production by vaginal flora in vitro is consistent with the rate and extent of vaginal acidification. Infect. Immun. 1999; 67: 5170-5.
  14. Boskey E.R., Cone R.A., Whaley K.J., Moench T.R. Origins of vaginal acidity: high D/L lactate ratio is consistent with bacteria being the primary source. Hum. Reprod. 2001; 16(9): 1809-13. doi: 10.1093/humrep/16.9.1809.
  15. Gorodeski G.I. Effects of estrogen on vaginal innervation: denervation or remodeling? Menopause. 2012; 19(6): 604-5. doi: 10.1097/gme.0b013e31824f5cbb.
  16. Schellenberg J.J., Dumonceaux T.J., Hill J.E., Kimani J., Jaoko W., Wachihi C. et al. Selection, phenotyping and identification of acid and hydrogen peroxide producing bacteria from vaginal samples of Canadian and East African women. PLoS One. 2012; 7(7) :e41217. doi: 10.1371/journal.pone.0041217.
  17. O’Hanlon D.E., Moench T.R., Cone R.A. Vaginal pH and microbicidal lactic acid when lactobacilli dominate the microbiota. PLoS One. 2013; 8(11): e80074. doi: 10.1371/journal.pone.0080074.
  18. Martin R., Suarez J.E. Biosynthesis and degradation of H2O2 by vaginal lactobacilli. Appl. Environ. Microbiol. 2010; 76(2): 400-5. doi: 10.1128/ AEM.01631-09.
  19. Cherpes T.L., Hillier S.L., Meyn L.A., Busch J.L., Krohn M.A. A delicate balance: risk factors for acquisition of bacterial vaginosis include sexual activity, absence of hydrogen peroxide-producing lactobacilli, black race, and positive herpes simplex virus type 2 serology. Sex. Transm. Dis. 2008; 35(1): 78-83.
  20. Vallor A.C., Antonio M.A., Hawes S.E., Hillier S.L. Factors associated with acquisition of, or persistent colonization by, vaginal lactobacilli: role of hydrogen peroxide production. J. Infect. Dis. 2001; 184(11): 1431-6.
  21. Mijac V.D., Dukic S.V., Opavski N.Z., Dukic M.K., Ranin L.T. Hydrogen peroxide producing lactobacilli in women with vaginal infections. Eur. J. Obstet. Gynecol. Reprod. Biol. 2006; 129: 69-76.
  22. Hillier S.L., Krohn M.A., Klebanoff S.J., Eschenbach D.A. The relationship of hydrogen peroxide-producing lactobacilli to bacterial vaginosis and genital microflora in pregnant women. Obstet. Gynecol. 1992; 79(3): 369-73.
  23. Strus M., Brzychczy-Wloch M., Gosiewski T., Kochan P., Heczko P.B. The in vitro effect of hydrogen peroxide on vaginal microbial communities. FEMS Immunol. Med. Microbiol. 2006; 48: 56-63.
  24. Ocaña V.S., de Ruiz Holgado A.A., Nader-Macías M.E. Growth inhibition of Staphylococcus aureus by H2O2-producing Lactobacillus paracasei subsp. paracasei isolated from the human vagina. FEMS Immunol. Med. Microbiol. 1999; 23(2): 87-92.
  25. Gupta K., Stapleton A.E., Hooton T.M., Roberts P.L., Fennell C.L., Stamm W.E. Inverse association of H2O2-producing lactobacilli and vaginal Escherichia coli colonization in women with recurrent urinary tract infections. J. Infect. Dis. 1998; 178(2): 446-50.
  26. Klebanoff S.J., Hillier S.L., Eschenbach D.A., Waltersdorph A.M. Control of the microbial flora of the vagina by H2O2-generating lactobacilli. J. Infect. Dis. 1991; 164: 94-100.
  27. O’Hanlon D.E., Moench T.R., Cone R.A. In vaginal fluid, bacteria associated with bacterial vaginosis can be suppressed with lactic acid but not hydrogen peroxide. BMC Infect. Dis. 2011; 11: 200. doi: 10.1186/1471-2334-11-200.
  28. O’Hanlon D.E., Lanier B.R., Moench T.R., Cone R.A. Cervicovaginal fluid and semen block the microbicidal activity of hydrogen peroxide produced by vaginal lactobacilli. BMC Infect. Dis. 2010; 10: 120. doi: 10.1186/1471-2334-10-120.
  29. Ravel J., Gajer P., Abdo Z., Schneider G.M., Koenig S.S., McCulle S.L. et al. Vaginal microbiome of reproductive-age women. Proc. Natl. Acad. Sci. USA. 2011; 108(Suppl. 1): 4680-7. doi: 10.1073/pnas.1002611107.
  30. Dumonceaux T.J., Schellenberg J., Goleski V., Hill J.E., Jaoko W., Kimani J. et al. Multiplex detection of bacteria associated with normal microbiota and with bacterial vaginosis in vaginal swabs by use of oligonucleotide-coupled fluorescent microspheres. J. Clin. Microbiol. 2009; 47(12): 4067-77. doi: 10.1128/ JCM.00112-09.
  31. Stanek R., Gain R.E., Glover D.D., Larsen B. High performance ion exclusion chromatographic characterization of the vaginal organic acids in women with bacterial vaginosis. Biomed. Chromatogr. 1992; 6: 231-5.
  32. Conti C., Malacrino C., Mastromarino P. Inhibition of herpes simplex virus type 2 by vaginal lactobacilli. J. Physiol. Pharmacol. 2009; 60(Suppl. 6): 19-26.
  33. Graver M.A., Wade J.J. The role of acidification in the inhibition of Neisseria gonorrhoeae by vaginal lactobacilli during anaerobic growth. Ann. Clin. Microbiol. Antimicrob. 2011; 10: 8. doi: 10.1186/1476-0711-10-8.
  34. Juárez Tomás M.S., Ocaña V.S., Wiese B., Nader-Macías M.E. Growth and lactic acid production by vaginal Lactobacillus acidophilus CRL 1259, and inhibition of uropathogenic Escherichia coli. J. Med. Microbiol. 2003; 52: 1117-24.
  35. Shukair S.A., Allen S.A., Cianci G.C., Stieh D.J., Anderson M.R., Baig S.M. et al. Human cervicovaginal mucus contains an activity that hinders HIV-1 movement. Mucosal Immunol. 2013; 6(2): 427-34. doi: 10.1038/mi.2012.87.
  36. Lai S.K., Hida K., Shukair S., Wang Y.Y., Figueiredo A., Cone R. et al. Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus. J. Virol. 2009; 83(21): 11196-200. doi: 10.1128/ JVI.01899-08.
  37. Mossop H., Linhares I.M., Bongiovanni A.M., Ledger W.J., Witkin S.S. Influence of lactic acid on endogenous and viral RNA-induced immune mediator production by vaginal epithelial cells. Obstet. Gynecol. 2011; 118(4): 840-6.
  38. Shime H., Yabu M., Akazawa T., Kodama K., Matsumoto M., Seya T., Inoue N. Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway. J. Immunol. 2008; 180(11): 7175-83.
  39. Witkin S.S., Alvi S., Bongiovanni A.M., Linhares I.M., Ledger W.J. Lactic acid stimulates interleukin-23 production by peripheral blood mononuclear cells exposed to bacterial lipopolysaccharide. FEMS Immunol. Med. Microbiol. 2011; 61(2): 153-8.
  40. Murray C.M., Hutchinson R., Bantick J.R. Monocarboxylate transporter MCT1 is a target for immunosuppression. Nat. Chem. Biol. 2005; 1(7): 371-6.
  41. Végran F., Boidot R., Michiels C., Sonveaux P., Feron O. Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-kB/IL-8 pathway that drives tumor angiogenesis. Cancer Res. 2011; 71(7): 2550-60.
  42. Кира Е.Ф., Прилепская В.Н., Костава М.Н., Гамирова Е.В., Довлетханова Э.Р., Душкина Е.А. и др. Современные подходы к выбору препарата локального действия в терапии бактериального вагиноза. Акушерство и гинекология. 2012; 7: 59-67. [Kira E.F., Prilepskaya V.N., Kostava M.N. et al. Modern approaches to the choice of locally applied drug in the therapy of bacterial vaginosis. Akusherstvo i ginekologiya/Obstetrics and Gynecology. 2012; 7: 59-67. (In Russian)]
  43. Кира Е.Ф., Душкина Е.А., Бадикова Н.С. Биологическая роль кислотности влагалища. Механизмы стабильности и методы коррекции. Акушерство и гинекология. 2013; 3: 102-6. [Kira E.F., Dushkina Е.А., Badikova N.S. Biological role of vaginal acidity. Stability mechanisms and correction methods. Akusherstvo i ginekologiya/Obstetrics and Gynecology. 2013; 3: 102-106. (In Russian)]
  44. Душкина Е.А. Роль кислотосодержащих препаратов в лечении бактериального вагиноза у женщин репродуктивного возраста: автореф. дис.. канд. мед. наук. М.; 2014. 24 с. [Dushkina Е.А. Role of acidic drugs in treatment of bacterial vaginosis in women of reproductive age. Diss. М.; 2014. 24 p. (In Russian)]

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