The specific features of an obstetric/gynecologic history in women and the risk factors of visceroabdominal disproportion in fetuses with gastroschisis


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Resumo

Objective. To determine the maternal factors influencing the development of a fetus, which are predictors for visceroabdominal disproportion (VAD) in gastroschisis. Subjects and methods. This investigation enrolled 80 women aged 15 to 34 years, including 60 women who had given birth to babies with gastroschisis without VAD (Group 1) and 20 women who had babies with VAD (Group 2). Data from their history and medical records were collected and analyzed. The influence of different maternal factors, such as age, bad habits (smoking), and prior infectious diseases and anemia during pregnancy, on the development of fetuses having gastroschisis with VAD, were assessed. Results. The major risk factors of the birth of a baby with gastroschisis, such as maternal age, smoking, and prior infections, anemia during pregnancy were comparatively assessed in two groups of women who had given birth to babies having gastroschisis with and without VAD in order to reveal their influence on the development of a fetus with VAD. The risk factors, such as smoking and anemia during pregnancy, were noted to be significantly more common in the group of women who had given birth to infants with VAD. At the same time, prior infections during pregnancy were 1.5-fold more frequently recorded in the women having babies without VAD. Conclusion. The investigation has revealed that the most important risk factors for the development of fetal gastroschisis with VAD are smoking during pregnancy, a compromised obstetric/gynecologic history (abortions, anemia), repeated pregnancies, and a maternal age of less than 20 years and that of more than 28 years. It is noted that there is a relationship of the use of analgesic, antipyretic, and nonsteroidal anti-inflammatory drugs in the first trimester of pregnancy to the increased risk of VAD in babies with gastroschisis.

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Sobre autores

O. Teplyakova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Doctor Anesthesiologist, Department of Surgery, Resuscitation and Intensive Care of Newborns

V. Zubkov

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

MD, Head of the Department of Neonatology and Pediatrics

A. Pyregov

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

MD, head of the department of anesthesiology and intensive care

Yu. Podurovskaya

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Head of Department of Surgery, Resuscitation and Intensive Care of Newborns, Pediatric surgeon

A. Burov

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Chief Clinician, Doctor Anesthesiologist, Department of Surgery, Resuscitation and Intensive Care of Newborns

E. Dorofeeva

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Pediatric surgeon, Department of Surgery, Resuscitation and Intensive Care of Newborns

E. Eroshenko

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

neonatologist, Department of Surgery, Resuscitation and Intensive Care of Newborns

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