SPECIFIC FEATURES OF ANTIOXIDANT DEFENSE IN THE MOTHER-PLACENTA-FETUS SYSTEM IN INTRAUTERINE INFECTION


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Resumo

Objective. To investigate the specific features of antioxidant defense in the mother-placenta-fetus system in intrauterine infection. Subjects and methods. Forty-seven pregnant women and their newborn infants underwent prospective examination including an analysis of their clinical characteristics and a study of the fragment of a regulatory cascade of antioxidant defense in intrauterine infection (Group 1 comprising 22 mother-newborn pairs) (a study group) and Group 2 consisting of 25 apparently healthy pairs (a control group). Results. The patients with intrauterine infection had much more frequently chronic urinary tract diseases, small pelvic inflammatory diseases, and a number of gestational complications, such as threatened miscarriage, isthmicocervical insufficiency, anemia, hypamnion, premature rupture of membranes, and fetal growth restriction than the controls. The plasma samples from pregnant women with intrauterine infection exhibited significantly enhanced catalase activity (p < 0.009). Analysis of the level of the enzyme superoxide dismutase in the tissue of umbilical cord Wharton’s jelly revealed significant differences between Groups 1 and 2 for a mitochondrial isoform (S0D2'). Conclusion. The impaired work of receptor systems to regulate the generation of reactive oxygen species in intrauterine infection suggest the depletion of adaptive resources of the mother and her developing fetus, which necessitates further investigations in this area to search for predictors and ways for therapeutically controlling the processes described.

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Sobre autores

Natalia Kan

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: kan-med@mail.ru
PhD, MD, the head of the obstetric observation department Moscow 117997, Ac. Oparina str. 4, Russia

Elena Sirotkina

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_sirotkina@oparina4.ru
the postgraduate student Moscow 117997, Ac. Oparina str. 4, Russia

Victor Tyutyunnik

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tioutiounnik@mail.ru
PhD, MD, the head of the obstetrical physiologic department Moscow 117997, Ac. Oparina str. 4, Russia

Mikhail Vyssokikh

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: m_vysokikh@oparina4.ru
PhD, the head of mitochondrial medicine research group Moscow 117997, Ac. Oparina str. 4, Russia

Tatiana Kurchakova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: t_kurchakova@oparina4.ru
the postgraduate student Moscow 117997, Ac. Oparina str. 4, Russia

Maria Volodina

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: m_volodina@oparina4.ru
PhD, researcher at mitochondrial medicine research group Moscow 117997, Ac. Oparina str. 4, Russia

Nadezhda Tarasova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_tarasova@oparina4.ru
PhD, researcher at mitochondrial medicine research group Moscow 117997, Ac. Oparina str. 4, Russia

Sofia Pyataeva

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: biosonya@gmail.com
PhD, researcher at mitochondrial medicine research group Moscow 117997, Ac. Oparina str. 4, Russia

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