ESR1 and VEGFA gene polymorphisms as a predictor for the course of ovarian hyperstimulation syndrome in an in vitro fertilization program
- Autores: Strelchenko D.A.1, Perminova S.G.1, Donnikov A.E.1
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Afiliações:
- Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
- Edição: Nº 5 (2017)
- Páginas: 90-97
- Seção: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247960
- DOI: https://doi.org/10.18565/aig.2017.5.90-7
- ID: 247960
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Resumo
Objective. To search for molecular genetic markers associated with different types of the clinical course of ovarian hyperstimulation syndrome (OHSS) in an IVF program. Subjects and methods. The clinical course of OHSS in the IVF program used in 59patients admitted to hospital for therapy aimed at relieving the symptoms of this complication. According to the onset of OHSS manifestations, the patients were divided into two groups: 1) 42 patients with early OHSS; 2) 17 patients with late OHSS. A wide panel of genetic markers also potentially involved in the development of clinical manifestations of OHSS was examined. The frequency of different alleles of each gene candidate was analyzed in two patient groups (with early and late OHSS). Results. The analysis of a relationship of candidate genes to the onset of OHSS manifestations revealed a statistically significant association of the VEGFA -2578(-2595) A>C [rs699947], VEGFA -634 G>C [rs2010963], ESR1 -351 A>G [Xbal] [rs9340799], and ESR1 -397 T> [PvulI] [rs2234693]polymorphisms with the onset of clinical manifestations of OHSS. According to an autosomal recessive model, the VEGFA -634G/Ggenotype and VEGFA -2578A/A genotype were associated with late OHSS (p = 0.016; OR = 5.87 (95% CI 1.22-28.19) and p = 0.035; OR = 2.38 (95% CI 1.05-5,38), respectively). Examination of ESR1 gene polymorphisms established that according to the autosomal recessive model, the -397C/C and -351G/G genotypes increased the risk of late OHSS (OR = 2.32 (95% CI 1.03-5.23);p = 0.039 and OR = 3.17(95% CI 1.38-7.28), p^ = 0.005, respectively). Analyzing the linkage of the examined VEGFA gene loci revealed a pronounced non-equilibrium coupling between the -2578A>C and-634 G>C loci and that of the -397C>T (PvuII) and -351G>A (XbaI) polymorphism loci in the ESR1 gene. Conclusion. The findings suggest that there is a possible difference in the early and late forms of OHSS in the molecular mechanisms of development determining the pathogenetic features of the course of this complication.
Palavras-chave
infertility, single nucleotide polymorphism, in vitro fertilization, ovarian hyperstimulation syndrome (OHSS), early OHSS, late OHSS, molecular genetic predictors, human chorionic gonadotropin, follicle-stimulating hormone, luteinizing hormone/human chorionic gonadotropin, estradiol, vascular endothelial growth factor, estrogen receptor 1, gene polymorphism
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Sobre autores
Daria Strelchenko
Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: da_strelchenko@mail.ru
graduate student
Svetlana Perminova
Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: perisvet@list.ru
MD, Leading Researcher of the 1st gynecological department
Andrey Donnikov
Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: a_donnikov@oparina4.ru
Ph.D., senior staff scientist of molecular-genetics Department
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