Effectiveness of preimplantation genetic screening in patients with recurrent miscarriage and infertility


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Resumo

Objective. To investigate the effectiveness of preimplantation genetic screening (POS) in the outcomes of assisted reproductive technology programs in patients with recurrent miscarriage and infertility. Subjects and methods. The prospective cohort study enrolled 196 women with infertility of different genesis, who had experienced 2 or more pregnancy losses in the first trimester of pregnancy. The patients were divided into groups according to the performance of POS using array comparative genomic hybridization. Results. Term delivery occurred in 35.4% of the patients undergoing PCS and in 17.0% of those who had not (OR for live births = 2.7; 95% CI = 1.3; 5.6). Conclusion. In patients with recurrent miscarriage and infertility, IVF/POS is a method to increase live birth rates, by selecting euploid embryos.

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Sobre autores

Olga Korotchenko

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: okorotchenko@mail.ru
M.D., Post-graduate student, Department of assistive technologies in infertility treatment

Anastasia Syrkasheva

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_syrkasheva@oparina4.ru
M.D., Ph.D., Researcher of the IVF Department

Nataliya Dolgushina

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_dolgushina@oparina4.ru
M.D., Ph.D., M.P.H., Head of R&D Department

Elena Kulakova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_kulakova@oparina4.ru
M.D., Ph.D., senior researcher, Department of assistive technologies in infertility treatment

Alina Dokshukina

Lomonosov Moscow State University

Email: dokshukina.aa@gmail.com
Undergraduate of the Faculty of Fundamental Medicine

Aleksey Ekimov

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: aekimov@gmail.com
the geneticist of Molecular-Genetics Department

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