Indocyanine green (ICG) for the detection of sentinel lymph nodes in patients with endometrial cancer

Zaur N. Ibragimov; Ибрагимов Заур Намигович; Nikolay A. Mikaya; Микая Николай Александрович; Yuri N. Trifanov; Трифанов Юрий Николаевич; Tatiana V. Gorodnova; Городнова Татьяна Васильевна; Khristina B. Kotiv; Котив Христина Богдановна; Maria G. Yakovleva; Яковлева Мария Георгиевна; Olga E. Lavrinovich; Лавринович Ольга Евгеньевна; Nikolay E. Bondarev; Бондарев Николай Эдуардович; Anna A. Sidoruk; Сидорук Анна Александровна; Olga A. Smirnova; Смирнова Ольга Алексеевна; Konstantin Dz. Guseinov; Гусейнов Константин Джамилиевич; Elena V. Bakhidze; Бахидзе Елена Вилльевна; Iryna E. Meshkova; Мешкова Ирина Евгеньевна; Elvina K. Bakaeva; Бакаева Эльвина Хисматуловна; Marianna G. Shikhzadaeva; Шихзадаева Марианна Гульмугамедовна; Elena A. Ul’rikh; Ульрих Елена Александровна; Adel F. Urmancheeva; Урманчеева Адель Федоровна; Igor V. Berlev; Берлев Игорь Викторович; Alexey M. Belyaev; Беляев Алексей Михайлович

doi:10.18565/aig.2020.1suppl.105-111

Indocyanine green (ICG) for the detection of sentinel lymph nodes in patients with endometrial cancer

Autores: Ibragimov Z.N.¹, Mikaya N.A.¹, Trifanov Y.N.¹, Gorodnova T.V.¹, Kotiv K.B.¹, Yakovleva M.G.¹, Lavrinovich O.E.¹, Bondarev N.E.¹, Sidoruk A.A.¹, Smirnova O.A.¹, Guseinov K.D.¹, Bakhidze E.V.¹, Meshkova I.E.¹, Bakaeva E.K.¹, Shikhzadaeva M.G.¹, Ul’rikh E.A.¹, Urmancheeva A.F.¹, Berlev I.V.¹, Belyaev A.M.¹
Afiliações:
1. Petrov National Medical Research Center of Oncology of Minzdrav of Russia
Edição: Nº 1S (2020): Supplement
Páginas: 105-111
Seção: Articles
URL: https://journals.eco-vector.com/0300-9092/article/view/248789
DOI: https://doi.org/10.18565/aig.2020.1suppl.105-111
ID: 248789

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Aim. To investigate the effectiveness of the ICG fluorescence technique in the detection of sentinel lymph nodes (SLN) in patients with endometrial cancer (EC). Materials and methods. The study comprised 100 patients with morphologically and clinically verified stage T1a-1bNxM0 EC, who were managed at the Petrov National Medical Research Center of Oncology of Minzdrav of Russia from September 2015 to September 2017. Results. The use of ICG resulted in the detection of220 SLNs in the whole study cohort (n = 100). Ninety (90%) patients were found to have bilateral SLNs. In 9/100 (9%), staining was detected only on one side. Only in one case, no SLNs were identified. The sensitivity, specificity, and accuracy of the method were 100%, 93%, and 93%, respectively. Numerous studies confirm the fact that in patients with EC, intraoperative detection, biopsy and morphological examination of SLNs contribute to a better assessment of regional lymphatic collectors, more accurate staging of the disease, and a patient-tailored surgery, which in turn can increase the overall survival of patients with EC. Conclusion. The use of the ICG fluorescence technique for the detection of SLNs in patients with EC allows effective and safe staging of the disease.

Palavras-chave

ICG, corpus uteri cancer, sentinel lymph node, ICG, fluorescence

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Bibliografia

Берлев И.В., Ульрих Е.А., Ибрагимов З.Н., и др. Возможности детекции сигнальных лимфатических узлов при раке эндометрия радиоизотопным и флуоресцентным (ICG) методами. Вопросы онкологии. 2017; 2: 304-8. eLIBRARY ID:29114517
Shepherd E.S., Lowe D.A. Targeted selective trachelo-colpectomy for preservation of fertility in a young woman with vaginal clear cell carcinoma. J. Obstet Gynaecol. 2010; 30(4): 420-1. doi: 10.3109/01443611003681428.
Vidal F., et al. Evaluation of the sentinel lymph node algorithm with blue dye labeling for early- stage endometrial cancer in a multicentric setting. Int. J. Gynecol. Cancer. 2013: 23: 1237-43. doi: 10.1097/IGC.0b013e31829b1b98
Morton D.L., et al. Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch. Surg. 1992; 127: 392-9. doi: 10.1001/ archsurg.1992.01420040034005
Kadkhodayan S., et al. Lymphatic mapping and sentinel node biopsy in endometrial cancer a feasibility study using cervical injection of radiotracer and blue dye. Nucl Med Rev Cent East Eur. 2014; 17: 55-8. doi: 10.5603/ NMR.2014.0017
Krag D.N., et al. Technical outcomes of sentinel lymph-node resection and conventional axillary- lymph-node dissection in patients with clinically nodenegative breast cancer: results from the NSABP B-32 randomised phase III trial. Lancet Oncol. 2007; 8: 881-8. doi: 10.1016/S1470-2045(07)70278-4
Zavagno G., et al. A randomized clinical trial on sentinel lymph node biopsy versus axillary lymph node dissection in breast cancer: results of the Sentinella. GIVOM trial. Ann. Surg. 2008; 247: 207-10. doi: 10.1097/SLA.0b013e31812e6a73
Kim C.H., Soslow R.A., Park K.J. Pathologic ultrastaging improves micrometastasis detection in sentinel lymph nodes during endometrial cancer staging. Gynecol Cancer. 2013; 23(5): 964-70. doi: 10.1097/IGC.0000000000000159
Bosquet G.J., et al. Cytokeratin staining of resected lymph nodes may improve the sensitivity of surgical staging for endometrial cancer. Gynecol. Oncol. 2003; 91: 518-25. doi: 10.1016/j.ygyno.2003.08.026

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Indocyanine green (ICG) for the detection of sentinel lymph nodes in patients with endometrial cancer

Texto integral

Resumo

Palavras-chave

Texto integral

Sobre autores

Zaur Ibragimov

Nikolay Mikaya

Yuri Trifanov

Tatiana Gorodnova

Khristina Kotiv

Maria Yakovleva

Olga Lavrinovich

Nikolay Bondarev

Anna Sidoruk

Olga Smirnova

Konstantin Guseinov

Elena Bakhidze

Iryna Meshkova

Elvina Bakaeva

Marianna Shikhzadaeva

Elena Ul’rikh

Adel Urmancheeva

Igor Berlev

Alexey Belyaev

Bibliografia

Arquivos suplementares

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