Progesterone-induced blocking factor: from molecular biology to clinical medicine


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Resumo

Pregnancy is a unique immunological situation when two allogeneic organisms live in close symbiosis without rejecting each other. Progesterone-induced blocking factor (PIBF) is a protein produced by activated lymphocytes in healthy pregnant women under the influence of progesterone. The specific immune tolerance of a mother to her fetus is known to be supported by several factors, which are the focus of current studies in the field of reproductive immunology. One of these factors is PIBF. It was originally discovered as a protein expressed by the peripheral lymphocytes in healthy pregnant women under the action of progesterone. PIBF performs immunomodulatory functions in vivo and in vitro, which are important for establishing maternal-fetal immune tolerance and therefore for the normal course of pregnancy. In recent years, several tumors producing PIBF have been identif ied; thus, it is possible to consider PIBF as a potential new tumor biomarker and to develop new therapeutic strategies in the future. Conclusion. PIBF is a unique protein that is not present in normal cells, but it can be found primarily in fastgrowing embryo tissues or cancer cells. This review presents the current views of the Russian and foreign scientists on progesterone-induced blocking factor and its role in reproduction and oncogenesis; the leading pathogenetic role of this factor in maintaining a normal pregnancy is demonstrated.

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Sobre autores

O. Prokhorova

Ural State Medical University, Ministry of Health of Russia

MD, PhD, Assistant Professor, Department of Obstetrics and Gynecology 620014, Russia, Yekaterinburg, Repin str., 3

A. Olina

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology; E.I. Vagner Perm State Medical University, Ministry of Health of Russia

Email: olina29@mail.ru
MD, PhD, DSci (Medicine), Professor, Deputy Director 199034, Russia, St. Petersburg, Mendeleevskaya line, 3

G. Tolibova

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology

MD, DSci (Medicine), Head of Immunohystochemistry Laboratory 199034, Russia, St. Petersburg, Mendeleevskaya line, 3

T. Tral

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology

MD, PhD, Pathologist, Head of Pathologic Laboratory 199034, Russia, St. Petersburg, Mendeleevskaya line, 3

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