CURRENT POSSIBILITIES OF TRANSCRIPTOMICS IN THE STUDY OF PREECLAMPSIA


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The paper deals with modern transcriptomics technologies in the study and solution of a significant obstetric problem, such as preeclampsia. Transcriptomics is currently one of the most rapidly developing areas of systems biology, bioinformatics, and medicine, which make it possible to get information about the functional activity of the genome, by analyzing all transcripts synthesized by one cell or a group of cells. The paper presents a literature review of recently published studies of placental transcriptome that is of great importance in expanding knowledge about the normal development and functioning of the placenta allows one to take into account the possible effect of fetal sex on the expression prof ile of a gene and is an indispensable tool for study ing the basic pathophysiological mechanisms of placental disorders. Genome-wide blood transcriptome analysis in pregnant women has shown multiple maternal gene expression pattern changes that are associated with preeclampsia just at the preclinical stage of its development, which will be able to identify the most accurate prognostic markers. The paper also highlights the issues of the intrauterine origin of diseases. It presents studies that have demonstrated the associations between genetic variants, changes in the placental transcriptome, and a risk for postnatal diseases. Conclusion: The paper indicates prospects for the integrated use of “omics” technologies in the study of causal mechanisms for the development of placental syndromes and in the prediction of pregnancy complications and offspring health.

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Sobre autores

Iraida SIDOROVA

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation

Email: sidorovais@yandexru
Dr. Med. Sci., Professor, Academician of the RAS, Honoured Scientist of the Russian Federation, Department of Obstetrics and Gynaecology No. 1, NV. Sklifosovsky Institute of Clinical Medicine Moscow, Russia

Natalya NIKITINA

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation

Email: natnikitina@list.ru
Dr. Med. Sci., Professor, Department of Obstetrics and Gynaecology No. 1, NV. Sklifosovsky Institute of Clinical Medicine Moscow, Russia

Mikhail AGEEV

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation

Email: mikhaageev@yandex.ru
PhD, Assistant at the Department of Obstetrics and Gynecology No. 1, NV. Sklifosovsky Institute of Clinical Medicine Moscow, Russia

Sergey TIMOFEEV

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation

Email: satimofeev30@gmail.com
Assistant at the Department of Obstetrics and Gynecology No. 1, N.V. Sklifosovsky Institute of Clinical Medicine Moscow, Russia

Ekaterina MOROZOVA

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation

Email: drstrelnikova@mail.ru
postgraduate student, Department of Obstetrics and Gynaecology No. 1, NV. Sklifosovsky Institute of Clinical Medicine Moscow, Russia

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