Assessment of the potential use of antioxidant support in infertility of various etiologies
- Autores: Berezina D.A.1, Karimova A.A.1
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Afiliações:
- Ural State Medical University, Ministry of Health of Russia
- Edição: Nº 7 (2024)
- Páginas: 22-27
- Seção: Reviews
- URL: https://journals.eco-vector.com/0300-9092/article/view/635278
- DOI: https://doi.org/10.18565/aig.2024.68
- ID: 635278
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Resumo
The options for infertility treatment increase and it is necessary to assess rationally the value of including additional substances in the algorithms for the management of patients. One of the most controversial issues remains the use of antioxidants. Although these substances have a positive effect on molecular levels, the results of their use in clinical practice can be very contradictory. To obtain an up-to-date and comprehensive view of the role of antioxidants in combating oxidative stress observed in various reproductive pathologies, we reviewed the world literature sources in Scopus, Web of Science, MedLine, Cochrane and other databases for the last five years. The data on potential mechanisms of antioxidant action in relation to molecular targets in the female reproductive system were summarized and analyzed. It was observed that the majority of foreign scientists were interested in the potential use of antioxidants in the treatment of infertility associated with endocrine disorders. The review pays special attention to the analysis of experience in the use of the most widely studied antioxidants in the treatment of unexplained infertility.
Conclusion: The analysis of the literature data demonstrated the considerable potential of natural antioxidants, but in most cases their use did not result in statistically significant clinical effects, even for the molecules most studied, such as vitamins C and E, alpha-lipoic acid, L-carnitine, and melatonin. The use of antioxidants in the treatment of unexplained infertility has had disappointing results so far. Nevertheless, there is still hope for achieving this ambitious therapeutic goal which justifies the need to continue further research on this issue.
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Sobre autores
Dinara Berezina
Ural State Medical University, Ministry of Health of Russia
Autor responsável pela correspondência
Email: dinara-berezina@mail.ru
ORCID ID: 0000-0003-4685-6771
PhD student, Department of Obstetrics and Gynecology
Rússia, YekaterinburgAlisa Karimova
Ural State Medical University, Ministry of Health of Russia
Email: otd.mspo@gmail.com
ORCID ID: 0000-0003-3500-096X
PhD, Associate Professor at the Department of Pharmacy
Rússia, YekaterinburgBibliografia
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