Hyaluronic acid in the correction of genitourinary syndrome of menopause in women after anticancer treatment

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Objective: To study the effectiveness of hyaluronic acid in the correction of genitourinary syndrome of menopause in cancer patients after antitumor treatment.

Materials and methods: The literature search was conducted in the electronic databases, namely PubMed, Scopus, Web of Science, Cochrane Library, ScienceDirect, Embase, PsycINFO using the keywords in Russian and English. The articles were published between 1987 and 2024.

Results: The symptoms of genitourinary syndrome of menopause have a long-term negative impact on the quality of life of women who underwent antitumor treatment for malignant neoplasms. In cases of hormone-dependent forms of the disease, and when patients refuse to receive menopausal hormone therapy, alternative treatment methods become necessary. Currently, there is no single standard for non-hormonal correction of genitourinary syndrome of menopause in this population. The use of hyaluronic acid in both non-injectable and injectable forms for cancer patients is an effective method for addressing problems associated with vulvovaginal atrophy. The safety of volume-forming substances based on hyaluronic acid has also been demonstrated in the absence of disease progression.

Conclusion: The analysis of the literature showed the potential for further research into the efficacy and safety of using hyaluronic acid including long-term follow-up to correct vulvovaginal changes in cancer patients after antitumor treatment. This research could help determine whether it should be included in the standard restorative treatment for these patients. Such an approach could improve the quality of life for this patient group and address a number of psychological and socio-economic issues.

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Sobre autores

Liana Mkrtchian

National Medical Research Radiological Centre, Ministry of Health of Russia; National Research Nuclear University, Moscow Engineering Physics Institute

Autor responsável pela correspondência
Email: liana.mko@gmail.com
ORCID ID: 0000-0002-5027-5331

Dr. Med. Sci., Head of the Department of Medical Rehabilitation and Rehabilitation Technologies, A. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Centre, Ministry of Health of Russia; Professor, Department of Obstetrics and Gynecology, Obninsk Institute for Nuclear Power Engineering, National Research Nuclear University, Moscow Engineering Physics Institute

Rússia, Obninsk; Obninsk

Marina Kukosh

National Medical Research Radiological Centre, Ministry of Health of Russia; Patrice Lumumba Peoples’ Friendship University of Russia

Email: manja70@inbox.ru
ORCID ID: 0000-0001-6481-1724

PhD, Senior Researcher at the Department of Medical Rehabilitation and Rehabilitation Technologies, A. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Centre, Ministry of Health of Russia; Associate Professor, Department of Oncology and Hematology, Medical Institute, P. Lumumba RUDN University

Rússia, Obninsk; Moscow

Anastasia Bychkova

National Medical Research Radiological Centre, Ministry of Health of Russia; Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: abychkova88@mail.ru
ORCID ID: 0000-0003-4855-8188

obstetrician-gynecologist, oncologist at the Department of Aesthetic Gynecology and Rehabilitation, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; PhD student, A. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Centre, Ministry of Health of Russia

Rússia, Obninsk; Moscow

Inna Apolikhina

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Email: i_apolikhina@oparina4.ru
ORCID ID: 0000-0002-4581-6295

Dr. Med. Sci., Professor, Head of the Department of Aesthetic Gynecology and Rehabilitation, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; Professor, Department of Obstetrics, Gynecology, Perinatology and Reproductology, Institute of Vocational Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Rússia, Moscow; Moscow

Sergey Ivanov

National Medical Research Radiological Centre, Ministry of Health of Russia; Patrice Lumumba Peoples’ Friendship University of Russia

Email: oncourolog@gmail.com
ORCID ID: 0000-0001-7689-6032

Dr. Med. Sci., Corresponding Member of the RAS, Director, A. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Centre, Ministry of Health of Russia; Professor, Department of Oncology and Radiology named after V.P. Kharchenko of Medical Institute, P. Lumumba RUDN University

Rússia, Obninsk; Moscow

Andrey Kaprin

Patrice Lumumba Peoples’ Friendship University of Russia; National Medical Research Radiological Centre, Ministry of Health of Russia

Email: kaprin@mail.ru
ORCID ID: 0000-0001-8784-8415

Dr. Med. Sci., Professor, Academician of the RAS, Academician of the Russian Academy of Education, Director, P. Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre, Ministry of Health of Russia; Director General, National Medical Research Radiological Centre, Ministry of Health of Russia; Head of the Department of Oncology and Radiology named after V.P. Kharchenko of the Medical Institute, P. Lumumba RUDN University

Rússia, Moscow; Moscow; Obninsk

Irina Zamulaeva

National Medical Research Radiological Centre, Ministry of Health of Russia; Joint Institute for Nuclear Research

Email: zamulaeva@mail.ru
ORCID ID: 0000-0002-6136-8445

Dr. Sci. (Bio), Professor, Head of Radiation Biochemistry Department, A. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Centre, Ministry of Health of Russia; Leading Researcher at the Laboratory of Radiation Biology

Rússia, Obninsk; Dubna

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