Optimization of drug therapy for early human papillomavirus-associated cervical epithelial damages


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Abstract

Objective. To study the efficacy and tolerability of inosine pranobex for the treatment of early cervical epithelial changes associated with human papillomavirus (HPV) in different regimens compared with each other and with a control group. Subject and methods. One hundred and twenty-eight reproductive-aged patients having cytological evidence of mild cervical dysplasia and/or colposcopic epithelial changes were examined. Group 1 (n = 48) received inosine pranobex for 28 days; Group 2 (n = 41) took this drug for 14 days; a control group (n = 39) was untreated. Evaluation of therapeutic effectiveness involved colposcopy, ectocervical and endocervical cytological examination, and determination of the time course of changes from HPV (DNA) loads. Results. The investigation showed the advantages of active management in the patients in detecting HPV-associated cervical epithelial damages of unknown genesis or low grade (low-grade squamous intraepithelial lesions, atypical squamous cells of undetermined significance). A six-month follow-up of such women demonstrated the high rate of virus elimination after the use of inosine pranobex. At the same time, better results were obtained after a 28-day treatment regimen with its good tolerability.

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About the authors

Anna G. Kedrova

Institute of Advanced Training, Federal Biomedical Agency of Russia

Email: kedrova.anna@gmail.com
MD, professor of obstetrics and gynecology department

Sergey A. Levakov

Institute of Advanced Training, Federal Biomedical Agency of Russia

Email: levakoff@yandex.ru
MD, professor of obstetrics and gynecology department

Natalia N. Chelnokova

Medical Sanitary Unit One Hundred and Seventy, Federal Biomedical Agency of Russia

Email: msdl70@extern.rsce.ru
Head Korolev, Moscow Regions

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