Modern technologies in the combination treatment of preinvasive cervical diseases
- Authors: Baranov S.B.1, Aminodova I.P.2, Posiseeva L.V.3
-
Affiliations:
- Ivanovo State Medical Academy, Ministry of Health of Russia
- OOO "Modern Medicine Clinic
- Peoples' Friendship University of Russia
- Issue: No 3 (2015)
- Pages: 62-66
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247397
- ID: 247397
Cite item
Open Access
Access granted
Abstract
Objective. To evaluate the efficiency of different therapies for cervical intraepithelial neoplasia (CIN) I-III. Subjects and methods. One hundred and thirteen patients with severe dysplasia were examined and treated; four groups were formed in accordance with performed treatment. Results. The most active epithelialization was noted after photodynamic therapy (PDT). Completed epithelialization after PDT alone was seen more frequently than after other therapy options. No cervical deformation was detected after PDT. Addition of PDT-induced excision caused an increase in the number of standard cytogram readings, followed by the most pronounced and long-term antiviral effect, and reduced the rate of the vaginal environmental alkalinization. Conclusion. PDT is a highly effective treatment option for cervical dysplasia, can avoid scarring after excision, provides an antiviral effect, and promotes vaginal microbiome normalization. This allows one to recommend that PDT should be incorporated into a complex of treatment for reproductive-aged women in particular.
Full Text
About the authors
Shamail Benyaminovich Baranov
Ivanovo State Medical Academy, Ministry of Health of Russia
Email: Samuil68@mail.ru
PhD, assistant professor, Department of Obstetrics and Gynecology
Izabella Petrovna Aminodova
OOO "Modern Medicine Clinic
Email: AminodovSI@mail.ru
PhD Ivanovo
Lubov Valentinovna Posiseeva
Peoples' Friendship University of Russia
Email: lvposiseeva@mail.ru
MD, professor, Department of Obstetrics and Gynecology
References
- Кулаков В.И., Манухин И.Б., Савельева Г.М., ред. Гинекология. Национальное руководство. М.: ГЭОТАР-Медиа; 2011. 1086 с. [Kulakov V.I., Manukhin I.B., Savelyeva G.M., eds. Gynecology. National guide. M.: GEOTAR Media, 2011: 1086 p. (in Russian)]
- Ашрафян Л.А., Киселев В.И., Муйжнек Е.Л. Патогенетическая профилактика рака репродуктивных органов. М.: Изд-во Димитрейд График Групп; 2009: 119-61. [Ashrafyan L.A., Kiselev V.I., Muyzhnek E.L. Pathogenetic prevention of cancer of the reproductive organs. M.: Univ Dimitreyd Schedule Group, 2009: 119-161. (in Russian)]
- Андосова Л.Д., Конторщикова К.Н. Папилломавирусная инфекция. Нижний Новгород; 2010: 10-50. [Andosova L.D., Kontorshchikova K.N. Papillomavirus infection. Nizhny Novgorod; 2010: 10-50. (in Russian)]
- Kalantari M., Karlsen F., Johansson B., Sigurjonsson T., Wärleby B., Hagmar B. Human papillomavirus findings in relation to cervical intraepithelial neoplasia grade: a study on 476 Stockholm women, using PСR for detection and typing of HPV. Hum. Pathol. 1997; 28(8): 899-904.
- Дамиров М.М. Радиоволновые, криогенные и лазерные технологии в диагностике и лечении в гинекологии. М.: БИНОМ; 2011: 83-271. [Damirov M.M. Radiowave, cryogenic and laser technologies in diagnosis and treatment in gynecology. M.: BINOM; 2011: 83-271. (in Russian)]
- Роговская С.И. Практическая кольпоскопия. М.: ГЭОТАР-Медиа; 2010: 153-200. [Rogovskaya S.I. Practical colposcopy. M.: GEOTAR Media, 2010: 153-200. (in Russian)]
- Стерн П.Л., Китченер Г.С., ред. Вакцины для профилактики рака шейки матки. 3-е изд. М.: МЕДпресс-информ; 2011: 21-96. [Stern P.L. Kitchener H.S., eds. Vaccines for the prevention of cervical cancer. M. MEDpress-Inform; 2011: 21-96. (in Russian)]
- Роговская С.И., Липова Е.В., ред. Шейка матки, влагалище, вульва. Физиология, патология, кольпоскопия, эстетическая коррекция. М.: Status Praesens; 2014: 309-77. [Rogovskaya S.I., Lipova E.V. Сervіх, vagina, vulva: physiology, pathology, colposcopy, aesthetic correction. M.: Status Praesens; 2014: 309-377. (in Russian)]
- Прилепская В.П., ред. Заболевания шейки матки, влагалища и вульвы. М.: МЕДпресс-информ; 2005: 133-254. [Prilepskaya V.N., ed. Diseases of the cervix, vagina and vulva. M.: MEDpress-inform; 2005: 133-254. (in Russian)]
- Балюзек Ф.В., Морозова С.И., Самойлова К.А., ред. Медицинская лазе-рология. СПб.: Мир и Семья-95; 2000: 6-72. [Balyuzek F.V., Morozova S.I., Samoylova K.A., EDS. Medical lazerology. SPb.: Peace and family-95; 2000: 6-72. (in Russian)]
- Беляева Л.А., Степанян А.А., Адамян Л.В. Основы флюоресцентной диагностики и фотодинамической терапии. Проблемы репродукции. 2004; 1: 6-11. [Belyaeva L.A., Stepanyan A.A., Adamyan L.V. Basics of fluorescence diagnosis and photodynamic therapy. Problems of reproduction. 2004, 1: 6-11. (in Russian)]
- Странадко Е.Ф. Механизмы действия фотодинамической терапии. Российский онкологический журнал. 2000; 4: 52-6. [Stranadko E.F. Mechanisms of action of photodynamic therapy. Ros. Oncol. Zh. 2000; 4: 52-56. (in Russian)]
- Hillemanns P., Korell M., Schmitt-Sody M., Baumgartner R., Beyer W., Kimmig R. et al. Photodynamic therapy in women with cervical intraepithelial neoplasia using topically applied 5-aminolevulinic acid. Int. J. Cancer. 1999; 81(1): 34-8.
- Monk B.J., Brewer C., VanNostrand K., Berns M.W., McCullough J.L., Tadir Y., Manetta A. Photodynamic therapy using topically applied dihematoporphyrin ether in the treatment of cervical intraepithelial neoplasia. Gynecol. Oncol. 1997; 64(1): 70-5.
- Spitzer M., Krumholz B.A. Photodynamic therapy in gynecology. Obstet. Gynecol. Clin. North Am. 1991;18(3): 649-59.
Supplementary files
