UROGENITAL CANDIDIASIS: PROBLEMS OF THERAPY AND POSSIBILITIES OF THEIR CORRECTION


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Abstract

Objective. To carry out a systematic analysis of research data on the etiological structure of urogenital candidiasis at the present stage, on the resistance of Candida to antifungal drugs, and on the possibilities of antifungal therapy for acute and recurrent forms of the disease. Material and methods. The review includes the data of foreign and Russian articles published on this topic in the past 10 years and found in Pubmed and E-library. Results. The paper highlights the etiological structure of urogenital candidiasis and gives the basic principles of therapy for the disease. It presents the results of current investigations of antifungal resistance in Candida. There is evidence for the use of the antifungal drug Zalain (sertaconazole) in the therapy of urogenital candidiasis. The major pharmacokinetic characteristics and advantages of sertaconazole are shown. The results of the investigations demonstrating the high efficiency and safety of Zalain therapy for urogenital candidiasis, including its recurrent form, are presented. Conclusion. The species-specific heterogeneity of urogenital candidiasis pathogens is currently one of the causes of therapy failures because of the development of resistance in some fungal species, mainly non-albicans Candida ones. The current investigations have demonstrated the pronounced fungicidal effect of sertaconazole and the minimal number of posttherapy recurrences compared to that observed during standard therapy with imidazoles and triazoles. The high efficacy, convenient-to-use regimen, and no side effects of sertaconazole (Zalain) allow it to be recommended for the therapy of acute and recurrent urogenital candidiasis, including those caused by nonalbicans Candida species.

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About the authors

Margarita R. Rakhmatulina

State Dermatovenereology and Cosmetology Research Center, Ministry of Health of Russia

Email: rahmatulina@cnikvi.ru
MD, associate professor, Deputy Director of research and clinical work Moscow 107076, Korolenko str. 3, bld. 6, Russia

Elena G. Tsoi

City Polyclinic Two Hundred and Nineteen, Moscow Healthcare Department

MD, dermatologist Moscow 125373, Yana Raydisa Boulevard 47, Russia

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