CHRONIC SYSTEMIC INFLAMMATION AND MITOCHONDRIAL DYSFUNCTION IN THE ORIGIN OF POLYCYSTIC OVARY SYNDROME


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详细

Objective. To carry out a systematic analysis of the current literature on the involvement of chronic systemic inflammation and mitochondrial dysfunction in the etiology and pathogenesis of polycystic ovary syndrome (PCOS) and in the development of its complications. Material and methods. The review included foreign and Russian papers published in the Pubmed journals in the past 10 years on this topic. Results. The paper summarizes the currently known ways of the involvement of mitochondrial dysfunction and chronic systemic and local inflammation in the development of PCOS. It describes possible ways to potentiate oxidative stress and systemic inflammation in PCOS, including in cases of the elevated blood concentrations of free fatty acids and glycation end products, hyperglycemia, hyperleptinemia, and damage accumulation in the mitochondria and mitochondrial DNA. Conclusion. There is accumulating evidence suggesting a positive inverse correlation between systemic inflammation and mitochondrial dysfunction in the origin of PCOS.

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作者简介

Elena Khashchenko

Email: khashchenko_elena@mail.ru
postgraduate student of the Department of Pediatric Gynecology, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia 117997, Russia, Moscow, Ac. Oparina str. 4

Darya Tsvirkun

Email: darunyat@gmail.com
PhD, researcher at mitochondrial medicine research group, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

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