Diagnosis and treatment of tumor-like lesions of the vulva

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The article presents a review of the literature and a series of clinical observations of rare tumor-like lesions of the vulva, including pyogenic granuloma, steatocystoma multiplex, steatocystoma multiplex in combination with Paget’s disease, cystic lymphangioma and melanosis.

The article provides a description of the history and clinical picture of the diseases, complaints, type of pathological focus in the vulva area, with particular emphasis on the key clinical characteristics required for the timely diagnosis of the disease.

Patients with rare tumor-like lesions of the vulva are often observed by gynecologists for long periods of time and are administered inappropriate conservative therapy, while in most cases surgical treatment is required. On the other hand, it is frequently observed that doctors perform surgery in situations where there is no indication for it or where it is performed inadequately.

Conclusion: To improve early diagnosis and timely adequate treatment of patients with rare tumor-like lesions of the vulva, it is necessary to analyze the clinical experience and the data obtained from international clinical observations, to accumulate knowledge, to classify it and to publish it in the specialised medical literature.

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作者简介

Alexander Zharov

Kuban State Medical University, Ministry of Health of Russia

Email: Zharov.1966@yandex.ru
ORCID iD: 0000-0002-5460-5959

Dr. Med. Sci., Professor, Department of Obstetrics, Gynecology and Perinatology of the FPC and PPP

俄罗斯联邦, 350063, Krasnodar, Sedin str., 4

Marina Slashcheva

Kuban State Medical University, Ministry of Health of Russia

编辑信件的主要联系方式.
Email: Marina98@inbox.ru
ORCID iD: 0009-0002-4047-1408

PhD student at the Department of Obstetrics, Gynecology and Perinatology of the FPC and PPP

俄罗斯联邦, 350063, Krasnodar, Sedin str., 4

Ekaterina Kolesnikova

Kuban State Medical University, Ministry of Health of Russia

Email: Jokagyno@rambler.ru
ORCID iD: 0000-0002-6537-2572

PhD, Associate Professor, Department of Obstetrics, Gynecology and Perinatology of the FPC and PPP

俄罗斯联邦, 350063, Krasnodar, Sedin str., 4

参考

  1. Akamatsu T., Hanai U., Kobayashi M., Miyasaka M. Pyogenic granuloma: a retrospective 10-year analysis of 82 cases. Tokai J. Exp. Clin. Med. 2015; 40(3): 110-4.
  2. Mishina A., Petrovici V., Foca E., Mishin I. Steatocystoma simplex of the vulva. Dermatol. Pract. Concept. 2024; 14(2): e2024072. https://dx.doi.org/10.5826/dpc.1402a72.
  3. McCartin T.L., Sitler C.A. A case of vulvar cavernous lymphangioma. Hawaii J Health Soc. Welf. 2019; 78(12): 356-8.
  4. De Giorgi V., Gori A., Salvati L., Scarfì F., Maida P., Trane L. et al. Clinical and dermoscopic features of vulvar melanosis over the last 20 years. JAMA Dermatol. 2020; 156(11): 1185-91. https://dx.doi.org/10.1001/jamadermatol.2020.2528.
  5. Жаров А.В., Колесникова Е.В., Пенжоян А.Г., Дряева Л.Г. Редкие опухолеподобные образования вульвы. Акушерство и гинекология. 2021; 6: 192-7. [Zharov A.V., Kolesnikova E.V., Penzhoyan G.A., Dryaeva L.G. Rare tumor-like masses in the vulva. Obstetrics and Gynecology. 2021; (6): 192-7 (in Russian)]. https://dx.doi.org/10.18565/aig.2021.6.192-197.
  6. Abreu-Dos-Santos F., Câmara S., Reis F., Freitas T., Gaspar H., Cordeiro M. Vulvar lobular capillary hemangioma: a rare location for a frequent entity. Case Rep. Obstet. Gynecol. 2016; 2016: 3435270. https:// dx.doi.org/10.1155/2016/3435270.
  7. Mahmoudnejad N., Zadmehr A., Madani M.H. Vulvar pyogenic granuloma in adult female population: a case report and review of the literature. Case Rep. Urol. 2021; 2021: 5525092. https://dx.doi.org/10.1155/2021/5525092.
  8. Kaleeny J.D., Janis J.E. Pyogenic granuloma diagnosis and management: a practical review. Plast. Reconstr. Surg. Glob. Open. 2024; 12(9): e6160. https://dx.doi.org/10.1097/GOX.0000000000006160.
  9. Arikan D.C., Kiran G., Sayar H., Kostu B., Coskun A., Kiran H. Vulvar pyogenic granuloma in a postmenopausal woman: case report and review of the literature. Case Rep. Med. 2011; 2011: 201901. https://dx.doi.org/10.1155/ 2011/201901.
  10. Koo M.G., Lee S.H., Han S.E. Pyogenic granuloma: a retrospective analysis of cases treated over a 10-year. Arch. Craniofac. Surg. 2017; 18(1): 16-20. https://dx.doi.org/10.7181/acfs.2017.18.1.16.
  11. Frydkjær A.G., Krogerus C., Løvenwald J.B. [Pyogenic granuloma]. Ugeskr. Laeger. 2021; 183(29): V12200898. (in Danish).
  12. Gao J., Fei W., Shen C., Shen X., Sun M., Xu N. et al. Dermoscopic features summarization and comparison of four types of cutaneous vascular anomalies. Front. Med. (Lausanne). 2021; 8: 692060. https://dx.doi.org/10.3389/fmed.2021.692060.
  13. Palaniappan V., Karthikeyan K. Steatocystoma multiplex. Indian Dermatol. Online J. 2023; 15(1): 105-12. https://dx.doi.org/10.4103/idoj.idoj_490_23.
  14. Oh S.W., Kim M.Y., Lee J.S., Kim S.C. Keratin 17 mutation in pachyonychia congenita type 2 patient with early onset steatocystoma multiplex and Hutchinson-like tooth deformity. J. Dermatol. 2006; 33(3): 161-4. https://dx.doi.org/10.1111/j.1346-8138.2006.00037.x.
  15. Gass J.K., Wilson N.J., Smith F.J., Lane E.B., McLean W.H., Rytina E. et al. Steatocystoma multiplex, oligodontia and partial persistent primary dentition associated with a novel keratin 17 mutation. Br. J. Dermatol. 2009; 161(6): 1396-8. https://dx.doi.org/10.1111/j.1365-2133.2009.09383.x.
  16. Lima A.M., Rocha S.P., Batista C.M., Reis C.M., Leal I.I., Azevedo L.E. Case for diagnosis. Steatocystoma multiplex. An. Bras. Dermatol. 2011; 86(1): 165-6. https://dx.doi.org/10.1590/s0365-05962011000100031.
  17. Plewig G., Wolff H.H., Braun-Falco O. Steatocystoma multiplex: anatomic reevaluation, electron microscopy, and autoradiography. Arch. Dermatol. Res. 1982; 272(3-4): 363-80. https://dx.doi.org/10.1007/BF00509068.
  18. Молочков В.А., Хлебникова А.Н., Молочкова Ю.В. Случай множественной стеатоцистомы. Российский журнал кожных и венерических болезней. 2017; 20(3): 140-2. [Molochkov V.A., Khlebnikova A.N., Molochkova Yu.V. Clinical case of multiple steatocystoma. Russian Journal of Skin and Veneral Diseases. 2017; 20(3): 140-2. (in Russian)]. https://dx.doi.org/10.18821/ 1560-9588-2017-20-3-140-142.
  19. Lam C., Funaro D. Extramammary Paget’s disease: summary of current knowledge. Dermatol. Clin. 2010; 28(4): 807-26. https://dx.doi.org/10.1016/ j.det.2010.08.002.
  20. Padrnos L., Karlin N., Halfdanarson T.R. Mayo clinic cancer center experience of metastatic extramammary Paget disease 1998-2012. Rare Tumors. 2016; 8(4): 6804. https://dx.doi.org/10.4081/rt.2016.6804.
  21. O'Meara S., Cullen I.M. Extra-mammary Paget's disease of the penis. Int. J. STD AIDS. 2023; 34(10): 735-9. https://dx.doi.org/10.1177/09564624231171196.
  22. Кауфман Р., Фаро С., Браун Д. Доброкачественные заболевания вульвы и влагалища. Пер. с англ. М.: БИНОМ; 2009: 170-210. [Kaufman R.H., Faro S., Brown D. Benign diseases of the vulva and vagina. Transl. from English. Moscow: BINOM; 2009: 170-210. (in Russian)].
  23. Hatta N., Yamada M., Hirano T., Fujimoto A., Morita R. Extramammary Paget’s disease: treatment, prognostic factors and outcome in 76 patients. Br. J. Dermatol. 2008; 158(2): 313-8. https://dx.doi.org/10.1111/ j.1365-2133.2007.08314.x.
  24. Heller D.S. Pigmented vulvar lesions—a pathology review of lesions that are not melanoma. J. Low Genit. Tract Dis. 2013; 17(3): 320-5. https:// dx.doi.org/10.1097/LGT.0b013e31826a38f3.

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2. Fig. 1. Type of PG. In the area of ​​the anterior half of the right labia minora, a reddish-gray formation is noted, up to 2.0 cm in diameter, protruding above the mucosa by 0.7 cm, without infiltration of the underlying tissues, painless upon palpation.

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3. Fig. 2. View of the vulva with MS of the labia majora

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4. Fig. 3. Combination of MS and Paget's disease of the vulva

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5. Fig. 4. Cystic lymphangioma of the vulva

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6. Fig. 5. A. Focal melanosis of the vulva; B. Diffuse melanosis of the vulva

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