Bacterial vaginosis and local antimicrobial activity in pregnant women


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Abstract

The authors studied the antimicrobial activity of vaginal discharge (VD) in varying bacterial vaginosis (BV) and the pH value of the vaginal contents, and the parameters of the obligate and facultative microflora. Forty-four pregnant women with BV and 9 without signs of this disease were examined. The severity of BV was found to correlate directly with the abundant bacterial microflora (correlation coefficient 0.883) and pH (0.871) and inversely with glucose concentrations (-0.961), the obligate microflora (-0.889), and antimicrobial activity (-0.936). With severer BV, there were reductions in the VD concentrations of lysozyme, calprotectin, and defensins. The authors do not rule out that the decreased VD antimicrobial activity caused by the presence of antimicrobial peptides results in the occurrence of VD.

About the authors

T E Karapetyan

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies

Email: tomamed02@mail.ru
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies

V G Arzumanyan

I. I. Mechnikov Research Institute of Vaccines and Sera, Russian Academy of Medical Sciences

I. I. Mechnikov Research Institute of Vaccines and Sera, Russian Academy of Medical Sciences

L M Komissarova

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies

Ye T Malbakhova

I. M. Sechenov Moscow Medical Academy

I. M. Sechenov Moscow Medical Academy

O A Serdyuk

I. I. Mechnikov Research Institute of Vaccines and Sera, Russian Academy of Medical Sciences

I. I. Mechnikov Research Institute of Vaccines and Sera, Russian Academy of Medical Sciences

L V Rumyantseva

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies

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