AUTOANTIBODIES TO GONADOTROPIC HORMONES AND TESTOSTERONE IN MALE INFERTILITY


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Objective. To study whether autoantibodies to human chorionic gonadotropin (hCG) and testosterone can be produced in male infertility. Subjects and methods. A study group comprised men with infertility and pathozoospermia (n=71). A control group included fertile men with normozoospermia (n=32). Autoantibodies to hCG and testosterone and IgG subclasses were determined in blood serum by enzyme-linked immunosorbent assay. Results. Production of IgM- and IgG-classes autoantibodies to hCG and testosterone (1-4 subclasses, mainly functionally active IgG1) was found in male infertility. Antibodies to hCG and testosterone were detected more frequently in the infertile men (40.8% and 25.4%, respectively) than in the fertile men (3.1%) (p<0.01). There was a high detection rate of the antibodies in idiopathic male infertility (54.5% and 39.4%, respectively), in patients with astenozoospermia, and/or oligozoospermia, azoospermia. Conclusion. Autoantibodies to hCG and testosterone may be considered as a possible etiological factor of male infertility.

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作者简介

I. MENZHINSKAYA

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: i_menzinskaya@oparina4.ru

G. TER-AVANESOV

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Yu. GAVRILOV

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

O. BEZNOSHCHENKO

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

L. VANKO

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

G. SUKHIKH

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

参考

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