RISK OF ANEUPLOIDY IN EMBRYOS OF MEN WITH PATHOZOOSPERMIA IN ASSISTED REPRODUCTIVE TECHNOLOGY PRACTICE (META-ANALYSIS)

Objective. To summarize data from primary studies of the risk for aneuploidy in the embryos obtained from infertile males with abnormal zoospermia (AZS) in the assisted reproductive technology (ART) programs. Design. Systematic review and meta-analysis. Search strategy. A search was made in the Pubmed and EMBASE databases. Inclusion criteria. Observational studies in English with a parallel control, which investigated the risk of embryonic aneuploidy depending on whether or not AZS is in men in the ART programs. Data search and analysis. Three investigators independently sought for suitable studies, defined whether they met the inclusion criteria, and extracted the data. Results. The analysis included three moderate evidence-based observational studies (a total of 257 patients who underwent 313 preimplantation genetic diagnosis (cycles). Meta-analysis using a fixed-effect model revealed a higher risk for embryonic aneuploidy in the couples with male AZS (OR, 1.41; 95% CI 1.15-1.73) than in the control group. At the same time, the risk of monosomy and trisomy was lower (OR, 0.75; 95% CI 0.56—0.98) and that of comorbidities was higher (OR, 1.24; 95% CI 0.94—1.63) in the group of men with AZS than in that of men with normal zoospermia. The study group showed a lower incidence of pregnancies (per transfer) (OR, 0.75; 95% CI 0.43—1.3) and (per cycle) (OR, 0.78; 95% CI 0.46—1.32) and implantation rates (OR, 0.76; 95% CI 0.49—1.19) than in the controls. Conclusion. The data available in the literature on a risk for embryonic aneuploidy in the couples male AZS are ambiguous and the studies dealing with this problem are scarce. There is a need for further high-quality methodology investigations to solve this urgent challenge of modern reproductology.

meta-analysis, embryonic aneuploidy, abnormal zoospermia, oligoasthenoteratozoospermia, oligozoospermia, teratozoospermia, preimplantation genetic diagnosis, fluorescence in-situ hybridization, assisted reproductive technologies, intracytoplasmic sperm injection, in vitro fertilization