ESTIMATION OF THE MRNA EXPRESSION OF CYTOKINE GENES IN THE ENDOMETRIUM IN CHRONIC ENDOMETRITIS


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Objective. To establish the specific features of the mRNA expression of the genes of cytokines, Toll-like receptors, and other markers for immunocompetent cells in endometrial tissues in chronic endometritis. Subject and methods. A real-time RT-PCR assay was used to examine 110 women, including 79 patients with chronic endometritis and 31 apparently healthy women. Results. The authors described the expression profile of cytokines in chronic endometritis, which was employed to propose a procedure for determining the probability of endometrial stromal fibrosis in chronic endometritis. Conclusion. It has been proposed to evaluate the significant process of endometrial stromal fibrosis from the mRNA expression of 6 genes: IL-1B, IL-2, IL-10, Foxp3, TLR9, and IL2Ra.

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作者简介

N. GOMBOLEVSKAYA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: gombolevskaya@yandex.ru

O. BURMENSKAYA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: bourmenska@mail.ru

T. DEMURA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: t_demura@oparina4.ru

L. MARCHENKO

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: l.a.marchenko@yandex.ru

E. KOGAN

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_kogan@oparina4.ru

D. TROFIMOV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: d_trofimov@oparina4.ru

G. SUKHIKH

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: g_sukhikh@oparina4.ru

参考

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