SYSTEMIC LUPUS ERYTHEMATOSUS AND SECONDARY ANTIPHOSPHOLIPID SYNDROME


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详细

The paper describes a clinical case of the course of two pregnancies in a woman with systemic lupus erythematosus (SLE) and secondary antiphospholipid syndrome (APS). The investigation was undertaken to assess pregnancy outcomes in a patient with secondary APS in the presence of SLE in relation to management tactics. This observation shows that the concurrence of severe abnormalities, such as SLE and APS, substantially worsens obstetric outcomes. However, timely detection of APS in women with SLE, the occurrence of pregnancy in remission of the underlying disease, adequately chosen therapy, and an interdisciplinary observation of such patients allow achievement of favorable outcomes of pregnancy.

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作者简介

E. FEDOROVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: KatrinaFedorova7@gmail.com

T. KIRSANOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

N. KLIMENCHENKO

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: natalite@list.ru

参考

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  2. Клюквина Н.Г. Антифосфолипидный синдром: клинические аспекты. Медицина неотложных состояний. 2007; 1(8): 17-21.
  3. Сervera R., Asherson R.A., Lie J.T. Clinicopathologic correlations of the antiphospholipid syndrome. Semin. Arthritis Rheum. 1995; 24(4): 262-72.
  4. Кошелева Н.М., Хузмиева С.И., Алекберова З.С. Системная красная волчанка. II. Влияние системной красной волчанки на исходы беременности. Научно-практическая ревматология. 2006; 2: 52-9.
  5. Багрий А.Э., Дядык А.И. Системная красная волчанка и беременность. Новости медицины и фармации: Кардиология. 2010; 327.
  6. Wilson W.A., Gharavi A.E., Koike T., Lockshin M.D., Branch D.W., Piette J.C. et al. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshope. Arthritis Rheum. 1999; 42(7): 1309-11.
  7. Miyakis S., Lockshin M.D., Atsumi T., Branch D.W., Brey R.L., Cervera R. et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J. Thromb. Haemost. 2006; 4(2): 295-306.
  8. Lubbe W.F., Pattison N., Liggins G.C. Antiphospholipid antibodies and pregnancy. N. Engl. J. Med. 1985; 313(21): 1350-1.

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