Immunological aspects of the pathogenesis of chronic endocervicitis in the presence of cicatricial deformity of the cervix uteri


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Abstract

Objective. To study the immunological aspects of the pathogenesis of chronic endocervicitis and to evaluate the efficiency of its surgical treatment in the presence of cicatricial deformity of the cervix uteri. Subject and methods. Clinical observations covered 100 patients with chronic nonspecific endocervicitis in the presence of cicatricial deformity of the cervix uteri. Plastic operations via dissection were used as a surgical technique. The clinical efficiency of the technique and changes in the cytokine profile of the cervical mucus plug were evaluated. Results. Prior to treatment, all the patients were found to have pronounced changes in the levels of inflammatory cytokines. Postoperative clinical convalescence was achieved in 75 of the 100 patients. Six months after treatment, the endocervical mucin level of inflammatory cytokines corresponded to the normal values in the majority of patients. Conclusion. Reconstructive plastic surgery via dissection promotes recovery of cervical functional adequacy, normalization of the vaginal microflora, and restoration of antiinfectious resistance of the reproductive tract, which can recommend it for the treatment of chronic endocervicitis in the presence of cicatricial deformity of the cervix uteri.

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About the authors

Anton Vladimirovich Molochkov

Peoples' Friendship University of Russia

Email: anton.molochkov@gmail.com
Department of Dermatovenereology, Faculty for Postgraduate Training of Medical Workers

Gaiane Ernestovna Bagramova

Peoples' Friendship University of Russia

PhD, Associate Professor, Department of Dermatovenerology

Stanislav Vyacheslavovich Murakov

N.A. Semashko Railway Clinical Hospital at the Lyublino Station, OAO "RZhD"

Email: dr.stanislav@list.ru
PhD, dermatovenerologist

Oleg Alexanderovich Maikov

N.A. Semashko Railway Clinical Hospital at the Lyublino Station, OAO "RZhD"

Email: maykov2012@yandex.ru
obstetrician-gynaecologist

Paulina Evgen'evna Seregina

N.A. Semashko Railway Clinical Hospital at the Lyublino Station, OAO "RZhD"

PhD, obstetrician-gynaecologist

Aleksandr Viktorovich Veredchenko

N.A. Semashko Railway Clinical Hospital at the Lyublino Station, OAO "RZhD"

Email: alexandr_v80@inbox.ru
PhD

Sergey Aleksandrovich Popkov

N.A. Semashko Railway Clinical Hospital at the Lyublino Station, OAO "RZhD"

Email: popkov1000@gmail.com
MD, Professor

References

  1. Becher N., Adams Waldorf K., Hein M., Uldbjerg N. The cervical mucus plug: structured review of the literature. Acta Obstet. Gynecol. Scand. 2009; 88(5): 502-13.
  2. Pudney J., Quayle A.J., Anderson D.J. Immunological microenvironments in the human vagina and cervix: mediators of cellular immunity are concentrated in the cervical transformation zone. Biol. Reprod. 2005; 73(6): 1253-63.
  3. Попков С.А., Чибисов С.М., Пустовалов Д.А., Попкова А.В., Синютина Е.А. Механизмы иммунологической защиты цервикального канала. Вестник Российского университета дружбы народов. Серия: Медицина. 2007; 1: 10-7.

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