Immunological aspects of the pathogenesis of chronic endocervicitis in the presence of cicatricial deformity of the cervix uteri

Objective. To study the immunological aspects of the pathogenesis of chronic endocervicitis and to evaluate the efficiency of its surgical treatment in the presence of cicatricial deformity of the cervix uteri. Subject and methods. Clinical observations covered 100 patients with chronic nonspecific endocervicitis in the presence of cicatricial deformity of the cervix uteri. Plastic operations via dissection were used as a surgical technique. The clinical efficiency of the technique and changes in the cytokine profile of the cervical mucus plug were evaluated. Results. Prior to treatment, all the patients were found to have pronounced changes in the levels of inflammatory cytokines. Postoperative clinical convalescence was achieved in 75 of the 100 patients. Six months after treatment, the endocervical mucin level of inflammatory cytokines corresponded to the normal values in the majority of patients. Conclusion. Reconstructive plastic surgery via dissection promotes recovery of cervical functional adequacy, normalization of the vaginal microflora, and restoration of antiinfectious resistance of the reproductive tract, which can recommend it for the treatment of chronic endocervicitis in the presence of cicatricial deformity of the cervix uteri.

cicatricial deformity of the cervix uteri, immunological homeostasis, chronic cervicitis, inflammatory cytokines