Complete maternal and fetal histocompatibility as one of the factors for preterm delivery and placental insufficiency


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Background. Parental histocompatibility prevents the recognition of paternal embryonic antigens from early pregnancy, which favors the development of different obstetric complications. Impaired trophoblast invasion processes in the first trimester of pregnancy give rise to late gestational complications: fetal growth retardation, preeclampsia, preterm delivery, and antenatal fetal death. Description. The paper describes a clinical case of the course and outcomes of 5 pregnancies in a patient with varying degrees of fetal histocompatibility. The poorest result was obtained after pregnancy where the fetus major histocompatibility complex antigens were similar to maternal in spite of performed therapy. Conclusion. Lymphocyte immune therapy in the patient with concurrent factors for miscarriage could achieve pregnancy prolongation up to 34 weeks and, as consequence, the birth of a viable child.

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作者简介

Olga Khoroshkeeva

Research center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: khoroshkeeva.olga@gmail.com
Рhysician of the Department of Pregnancy Loss Prevention and Therapy

Nana Tetruashvili

Research center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: n_tetruashvili@oparina4.ru
Doctor of Medicine, Head of the Department of Pregnancy Loss Prevention and Therapy

Anna Agadzhanova

Research center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: tetrauly@mail.ru
Doctor of Medicine, leading researcher of the Department of Pregnancy Loss Prevention and Therapy

Olga Burmenskaya

Research center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: bourmenska@mail.ru
DSc Dоctor in medical sciences, researcher of Laboratory of molecular genetic methods

Dmitry Trofimov

Research center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: d_troflmov@oparina4.ru
DSc Ph.D. in medical sciences, Head of Laboratory of molecular genetic methods

参考

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