Opportunities for using gonadotropin-releasing hormone agonist for luteal phase support in the in vitro fertilization program


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Aim. To investigate the effectiveness of in vitro fertilization (IVF) programs in which the luteal phase support (LPS) was administered in the form of either a combined regimen of gonadotropin-releasing hormone agonist (GnRH-a) and micronizedprogesterone or the standard LPS regimen of micronizedprogesterone. Material and methods. The study comprised 207patients under the age of 38 years with tubo-peritoneal, male, and mixed factor infertility. On the day of transvaginal puncture (TVP), the patients were randomized into two groups with different LPS regimens. In group 1 (n = 92) patients received natural micronized progesterone 600 mg/day given vaginally from day 1 after TVP and a single subcutaneous dose of 0.1 mg trptorelin on day 6 after the TVP. Patients in group 2 (n = 115) were administered vaginal natural micronized progesterone 600 mg/day alone from day 1 after TVP. Results. The patients managed with the combined LPS regimen had higher rates of implantation (30.6 and 16.6%, p <0.05), clinical pregnancy (40.2 and 26.9%, p = 0.04), progressive pregnancy (36.9 and 21.7%, p = 0.01), and live birth rates (31.5 and 19.1%, p = 0.04) compared with patients treated with the standard LPS regimen. Conclusion. Using the combined LPS regimen with GnRH-a has a positive effect on the IVFprogram outcomes in protocols with GnRH antagonists.

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作者简介

Svetlana Perminova

National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov

Email: perisvet@list.ru
Dr.Med.Sci., Leading Researcher at the Department of Gynecology #1

Elena Mityurina

National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov

Email: mity-elena@yandex.ru
Ph.D., Physician at the Department of Gynecology #1

Elena Savelyeva

National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov

Email: elena-galliamova@rambler.ru
Ph.D. Student at the Department of Gynecology #1

参考

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