Justification for the efficiency of using aminodihydrophthalasindione sodium in the combination treatment of chronic endometritis in girls with recurrent uterine bleeding

Objective. To evaluate the efficiency of combination anti-inflammatory therapy using aminodihydrophthalasindione sodium in patients with recurrent uterine bleeding. Subjects and methods. The investigation enrolled 60 girls aged 12 to 17 years with recurrent uterine bleeding and chronic inflammatory disease of the uterus. All the patients received hemostatic and anti-inflammatory therapy in accordance with the standard of management of patients with uterine bleeding. In Group 1 were treated with an antibacterial and nonsteroidal anti-inflammatory drug. Patients of group 2 additionally received aminodihydrophthalasindione sodium injections. Results. A regular menstrual rhythm with a significantly higher frequency (66.7%) was found in the patients from Treatment Group 2. Recurrent uterine bleeding that occurred twice more frequently in Group 1 (60.0%). The indirect ultrasound signs of a chronic inflammatory process in the endometrium were re-identified only in patients with recurrent bleeding. Moreover, the detection rate of these signs after the end of treatment was higher in Group 1 patients (83.3%) than in Group 2 adolescents (40.0%). Conclusion. The presented investigation results demonstrate the efficacy and safety of aminodihydrophthalasindione sodium used as part of combination anti-inflammatory therapy in patients with recurrent abnormal uterine bleeding.

recurrent uterine bleeding, adolescents, chronic endometritis