A clinical case of cerebral sinus thrombosis during pregnancy after cryopreserved in vitro fertilization


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Background. Cerebral venous thrombosis is a rare, but life-threatening condition that is now becoming increasingly common in obstetric and gynecological practice due to the widespread use of hormone therapy and assisted reproductive technologies. Description. The paper presents a clinical case of cerebral sinus thrombosis during pregnancy after cryopreserved in vitro fertilization. It analyzes risk factors for cerebral venous thrombosis during pregnancy, the validity of pregnancy management tactics, and the choice of anticoagulant therapy. Conclusion. Cerebral thrombosis can develop in the absence of classical thrombophilia in the presence of antithrombin IIIdeficiency and imbalance in the von Willebrand factor/ADAMTS13system due to hyperestrogenia. Adequately chosen anticoagulant therapy in patients after cerebrovascular thrombosis prevents recurrences, the development of thrombosis of other localizations, and placenta-associated pregnancy complications.

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作者简介

Svetlana Akinshina

The First I.M. Sechenov Moscow State Medical University

Email: gemostasis@mail.ru
PhD, doctoral candidate of the Department of Obstetrics and Gynecology

Ismail Elalami

The First I.M. Sechenov Moscow State Medical University; Medicine Sorbonne University

Email: gemostasis@mail.ru
professor of obstetrics and gynecology department

Alexander Vorobyev

The First I.M. Sechenov Moscow State Medical University

Email: alvorobev@gmail.com
PhD, Associate Professor of the Department of Obstetrics and Gynecology

Viktoria Bitsadze

The First I.M. Sechenov Moscow State Medical University

Email: gemostasis@mail.ru
MD, Professor of the Russian Academy of Sciences, Professor of the Department of Obstetrics and Gynecology

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