Epidemiology of human papillomavirus infection and HPV-associated female genital cancers in the Sverdlovsk region

Implementation of the cancer prevention program showed the need to investigate regional epidemiological features of human papillomavirus infection and HPV-associated female genital cancers in the Sverdlovsk region. Aim. To identify the main epidemiological patterns of the prevalence of human papillomavirus infection, HPV-associated female genital cancers in the Sverdlovsk region for the scientific validation of the criteria for the adoption of the regional Preventive Screening and Vaccination Program. Materials and methods. This was a prospective cohort study of 2567 women. Also, a retrospective study of the oncological morbidity of the reproductive organs in the Sverdlovsk region was conducted based on official statistics from 2008 to 2018. Results. HPV DNA was detected in 48.8% of women, of which 67.7 ± 6.5% had high-risk oncogenic HPV types. The incidence of malignant neoplasms in the Sverdlovsk region was 431.1 per 100,000 of the population and 11.7% of them were HPV-associated. During the study period, the incidence of cervical cancer increased in the region by 24.3%, with a mean annual increase of 2.2%. Among cancers of rare locations, there was a significant 36.7% increase in the incidence of vulvar cancer. Conclusion Unfavorable epidemiologic changes in HPV-associated diseases in the Sverdlovsk region may serve as a scientific rationale for optimizing screening and adopting a regional preventive vaccination program.

papillomavirus infection, HPV-associated cervical cancer