New technologies in solving the problems of preeclampsia


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This review deals with the current state of the problem of preeclampsia in obstetrics. It is emphasized that hypertensive disorders and preeclampsia still retain their positions among the leading causes of maternal death in Russia in the presence of a progressive increase in the incidence of severe preeclampsia. The high percentage of preventable and potential preventable cases of maternal death due to preeclampsia (72.5% in 2020) suggests that there is a need for further improvement of the management strategy for these patients, as well as a deeper study of the pathophysiological mechanisms responsible for the development of this pregnancy complication. The paper emphasizes that the concept of failure of cytotrophoblast invasion as a cause of preeclampsia is currently in doubt. Taking into account the modern principles of personalized medicine, there is a need for innovative large-scale, high-throughput, unbiased researches. These requirements are met by the latest methods in systems biology, in particular, the so-called omics technologies (genomics, epigenetics, transcriptomics, proteomics, and metabolomics). The paper presents studies published in the largest databases on the use of omics technologies in the study of preeclampsia. Conclusion: A comprehensive study of the structure of a genome, as well as many ways of implementing genetic information (a systematic multi-omic design) will be able to gain a complete idea of the physiological and pathological processes, including preeclampsia.

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作者简介

Natalya Nikitina

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation

Email: natnikitina@nst.ru
Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology No. 1

Fraida Sidorova

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation

Email: sidorovais@yandex.ru
Academician of the RAS, Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology No. 1

Mikhail Ageev

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation

Email: mikhaageev@yandex.ru
PhD, Associate Professor at the Department of Obstetrics and Gynecology No. 1

Sergej Timofeev

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation

Email: satimofeev30@gmail.com
Teaching Assistant at the Department of Obstetrics and Gynecology No. 1

Marina Kiryanova

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation

Email: kiryanova.marina8@mam.ru
graduate student at the Department of Obstetrics and Gynecology No. 1

Ekaterina Morozova

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation

Email: drstrelnikova@mail.ru
graduate student at the Department of Obstetrics and Gynecology No. 1

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