INTERLEUKIN GENE POLYMORPHISM AND RISK OF UTERINE FIBROIDS


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Relevance: Uterine fibroids are common tumors of the female reproductive organs which affect 15-45% of women. Pathogenesis of uterine fibroids is characterized by impaired apoptosis and immune processes due to cytokine disbalance, namely interleukins. Interleukin gene polymorphism can affect their expression and as a result it plays an important role in pathophysiology of uterine fibroids. Objective: To study the correlation between interleukin gene polymorphism and uterine fibroids. Materials and methods: The study included 492patients. The main group consisted of109patients suffering from uterine fibroids. Six polymorphic loci of interleukin genes were selected for the study, namely A/C IL10 rs1800872, C/G IL6 rs1800795, T/C IL5 rs2069812, C/TIL4 rs2243250, T/C IL1β rs16944, C/T IL1α rs1800587. The analysis was performed using polymerase chain reaction (PCR) on a CFX-96 Real-Time System thermal cycler. The odds ratio (OR) and 95% confidence interval (CI) were used to calculate the associations. The association of combinations of the gene alleles and genotypes with the formation of uterine fibroids was evaluated on the basis of the APSampler software (https://sourceforge.net/projects/apsampler /). Results: Molecular genetic markers A/C IL10 rs1800872, T/C IL5 rs2069812, S/T IL4 rs2243250, T/C IL1β rs16944, S/T IL1α rs1800587play a significant role in the development of uterine fibroids. Such genotype as TT rs1800587IL1α (OR=5.70, p=0.017), as well as a combination of polymorphic variants of Trs2243250 IL4, T rs1800587 IL1a and Trs16944 IL1β (OR=2.60, pperm =0.012), T rs1800587 IL1a, C rs2069812 IL5 and T rs16944 IL1β (OR=2.60, p =0.012), T rs1800587 lL1a, C rs2069812 IL5 and T rs16944 IL1β (OR=2.71, pperm =0.009), T rs1800587 IL1a, C rs1800872 IL10 and T rs16944 IL1β (OR=2.73, pperm=0.003) should be considered risk factors for the development of uterine fibroids. Conclusion: Polymorphic gene loci A/C IL10 rs1800872, T/C IL5 rs2069812, S/T IL4rs 2243250, T/C IL1β rs16944, S/TIL1α rs1800587are associated with the development of uterine fibroids. We identified combinations of allelic variants of polymorphic loci of interleukin genes associated with an increased risk of uterine fibroids. These combinations indicate the importance of inter-locus interactions of candidate genes in the development of this pathology. In practical medicine they can be used to identify risk groups and to carry out preventive measures.

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作者简介

O. ALTUKHOVA

Belgorod National Research Universit

Email: kristalinka@yandex.ru
Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology, Medical Institute Belgorod, Russia

Viktor RADZINSKY

Peoples' Friendship University of Russia (RUDN University)

Email: radzinskiy-ve@rudn.ru
Dr. Med. Sci., Professor, Honored Scientist of the Russian Federation, Academician of the International Academy of Sciences of the Higher School, Head Department of Obstetrics and Gynecology, Faculty of Medicine, RUDN University Moscow, Russia

Svetlana SIROTINA

Belgorod National Research Universit

Email: sirotina@bsu.edu.ru
PhD (Bio), Associate Professor at the Department of Biomedical Disciplines Belgorod, Russia

Mikhail CHURNOSOV

Belgorod National Research Universit

Email: churnosov@bsu.edu.ru
Dr. Med. Sci., Professor, Head of the Department of Biomedical Disciplines of the Medical Institute Belgorod, Russia

Olga EFREMOVA

Belgorod National Research Universit

Email: efremova@bsu.edu.ru
Dr. Med. Sci., Associate Professor, Head of the Department of Faculty Therapy of the Medical Institute Belgorod, Russia

Irina BATLUTSKAYA

Belgorod National Research Universit

Email: bat@bsu.edu.ru
Dr. Med. Sci., Associate Professor, Head of the Department of Biotechnology and Microbiology Belgorod, Russia

Valentina ORLOVA

Belgorod National Research Universit

Email: orlova@bsu.edu.ru
Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology of the Medical Institute Belgorod, Russia

参考

  1. Alsudairi H.N., Alrasheed A.T., Dvornyk V. Estrogens and uterine fibroids: an integrated view. Research Results in Biomedicine. 2021; 7(2): 156-63. https://dx.doi.org/10.18413/2658-6533-2021-7-2-0-6.
  2. Aninye I.O., Laitner M.H. Uterine fibroids: assessing unmet needs from bench to bedside. J. Womens Health (Larchmt). 2021; 30(8): 1060-7. https://dx.doi.org/10.1089/jwh.2021.0280.
  3. Giuliani E., As-Sanie S., Marsh E.E. Epidemiology and management of uterine fibroids.Int. J. Gynaecol. Obstet. 2020; 149(1): 3-9. https://dx.doi.org/10.1002/ijgo.13102.
  4. Baranov V.S., Osinovskaya N.S., Yarmolinskaya M.I. Pathogenomics of uterine fibroids development.Int. J. Mol. Sci. 2019; 20(24): 6151. https://dx.doi.org/10.3390/ijms20246151.
  5. Manta L., Suciu N., Toader O., Purcärea R.M., Constantin A., Popa F. The etiopathogenesis of uterine fibromatosis. J. Med. Life. 2016; 9(1): 39-45.
  6. Aggarwal R., Jain A.K., Mittal P., Kohli M., Jawanjal P., Rath G. Association of pro- and anti-inflammatory cytokines in preeclampsia. J. Clin. Lab. Anal. 2019; 33(4): e22834. https://dx.doi.org/10.1002/jcla.22834.
  7. McWilliams M.M., Chennathukuzhi V.M. Recent advances in uterine fibroid etiology. Semin. Reprod. Med. 2017; 35(2): 181-9. https://dx.doi.org/10.1055/s-0037-1599090.
  8. Олейник Н.С. Современные представления о морфо- и патогенезе миомы матки (обзор литературы). Таврический медико-биологический вестник. 2011; 14 (3-2): 251-4
  9. Shen Z., Li S., Sheng B., Shen Q., Sun L.Z., Zhu H., Zhu X. The role of atorvastatin in suppressing tumor growth of uterine fibroids. J. Transl. Med. 2018; 16(1): 53. https://dx.doi.org/10.1186/s12967-018-1430-x.
  10. Place D.E., Kanneganti T.-D. Cell death-mediated cytokine release and its therapeutic implications. J. Exp. Med. 2019; 216(7): 1474-86. https://dx.doi.org/10.1084/jem.20181892.
  11. Ulin M.,Ali M., Chaudhry Z.T., Al-Hendy A., Yang Q. Uterine fibroids in menopause andperimenopause.Menopause. 2020;27(2):238-42. https://dx.doi.org/10.1097/GME.0000000000001438.
  12. Радзинский В.Е., Алтухова О.Б. Молекулярно-генетические детерминанты бесплодия при генитальном эндометриозе. Научные результаты биомедицинских исследований. 2018; 4(3): 28-37. https://dx.doi.org/10.18413/2313-8955-2018-4-3-0-3.
  13. Watza D., Lusk C.M., Dyson G., Purrington K.S., Chen K., Wenzlaff A.S. et al. Prognostic modeling of the immune-centric transcriptome reveals interleukin signaling candidates contributing to differential patient outcomes. Carcinogenesis. 2018; 39(12): 1447-54. https://dx.doi.org/10.1093/carcin/bgy119.
  14. Алтухова О.Б., Радзинский В.Е., Полякова И.С., Чурносов М.И. Вовлеченность полиморфизма генов рецепторов эстрогенов и прогестерона в развитие миомы матки. Акушерство и гинекология. 2020; 3: 127-32. https://dx.doi.org/10.18565/aig.2020.3.127-132.
  15. Vang Q., Mas A., Diamond M.P., Al-Hendy A. The mechanism and function of epigenetics in uterine leiomyoma development. Reprod. Sci. 2016; 23(2): 163-75. https://dx.doi.org/10.1177/1933719115584449.
  16. Пономаренко И.В., Полоников А.В., Чурносов М.И. Полиморфные локусы гена LHCGR, ассоциированные с развитием миомы матки. Акушерство и гинекология. 2018;(10):86-91. https://dx.doi.org/10.18565/aig.2018.10.86-91.]
  17. Machado-Lopez A., Simön C., Mas A. Molecular and cellular insights into the development of uterine fibroids.Int. J. Mol Sci. 2021;22(16):8483. https://dx.doi.org/10.3390/ijms22168483.
  18. Пономаренко И.В., Полоников А.В., Чурносов М.И. Ассоциация полиморфизма rs4986938 гена ESR2 с развитием гиперплазии эндометрия. Акушерство и гинекология. 2019; 4: 66-72. https://dx.doi.org/10.18565/aig.2019.4.66-72.
  19. Пономаренко И.В., Чурносов М.И. Современные представления об этиопатогенезе и факторах риска лейомиомы матки. Акушерство и гинекология. 2018;8: 27-32. https://dx.doi.org/10.18565/aig.2018.8.27-32.
  20. McWilliams M.M., Chennathukuzhi V.M. Recent advances in uterine fibroid etiology. Semin. Reprod. Med. 2017; 35(2): 181-9. https://dx.doi.org/10.1055/s-0037-1599090.
  21. Konenkov V.I., Koroleva E.G., Orlov N.B., Prokofev V.F., Shevchenko A.V, Novikov A.M., Dergacheva T.I. Blood serum levels of proinflammatory cytokines (IL-1ß, IL-6, TNFa, IL-8, IL-12p70, and IFNy) in patients with uterine myoma. Bull. Exp. Biol. Med. 2018; 165(5): 698-701. https://dx.doi.org/10.1007/s10517-018-4245-0.
  22. Favorov A.V., Andreewski T.V., Sudomoina M.A., Favorova O.O., Parmigiani M.F. A Markov chain Monte Carlo technique for identification of combinations of allelic variants underlying complex diseases in humans. Genetics. 2005; 171(4): 2113-21. https://dx.doi.org/10.1534/genetics.105.048090.
  23. Che R., Jack J.R., Motsinger-Reif A.A., Brown C.C. An adaptive permutation approach for genome-wide association study: evaluation and recommendations for use. BioData. Min. 2014; 7: 9. https://dx.doi.org/10.1186/1756-0381-7-9.
  24. Baker K.J., Houston A., Brint E. IL-1 family members in cancer: two sides to every story. Front. Immunol. 2019; 10: 1197. https://dx.doi.org/10.3389/fimmu.2019.01197.
  25. Brodzikowska А., Görska R., Kowalski J.Interleukin-1 genotype in periodontitis. Arch. Immunol. Ther. Exp. (Warsz). 2019; 67(6): 367-73. https://dx.doi.org/10.1007/s00005-019-00555-4.
  26. Chen G., Hu C., Song Y., Zhang H., Li S., Lai P. et al. Effects of IL-4-590C/ T (rs2243250) polymorphism on the susceptibility of smoking-related cancer: a meta-analysis involving 11,407 subjects. Biomed. Res.Int. 2019; 2019: 3104176. https://dx.doi.org/10.1155/2019/3104176.
  27. Celik M.Ö., Labuz D., Keye J., Glauben R., Machelska H. IL-4 induces M2 macrophages to produce sustained analgesia via opioids. JCI Insight. 2020; 5(4): e133093. https://dx.doi.org/10.1172/jci.insight.133093.
  28. Mestiri S., Zaaber I., Inoubli O., Abid N., Omrani A., Nejehi H., Marmouch H. Association of cytokine Th2 gene polymorphisms with autoimmune thyroid diseases in Tunisian population.Int. J. Immunogenet. 2020; 47(3): 294-308. https://dx.doi.org/10.1111/iji.12472.
  29. Gallegos-Arreola M.P., Zuniga Gonzalez G.M., Figuera L.E., Puebla Pérez A.M., Delgado Saucedo J.I. Association of the IL-10 gene rs1800872 (-592 C>A) polymorphism with breast cancer in a Mexican population. J. BUON. 2019; 24(6): 2369-76.
  30. Wang K., Jiao Z., Chen H., Liu X., Lu J. et al. The association between rs1800872 polymorphism in interleukin-10 and risk of cervical cancer: a meta-analysis. Medicine (Baltimore). 2022; 100(3): e23892. https://dx.doi.org/10.1097/MD.0000000000023892.

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