Diagnosis and topical therapy of lichen ruber planus in women

The term lichen ruber planus (LRP) is understood as a chronic inflammatory disease of the skin and mucous membranes, including the genitals, which is caused by CD8+ cytotoxic T lymphocytes. Despite the fact that the dermatosis was described more than 100 years ago, the exact causes of its development have not been identified to date. There is an increase in the number of cases of genital LRP concurrent with lichen sclerosus, focal neurodermatitis, atrophic vulvovaginitis, genitourinary syndrome, vulvar candidiasis, desquamative vaginitis, herpetic and papillomavirus infections. The review summarizes an update on the dinical presentations of genital LRP, diagnosis, treatment approaches, drug dosage regimens, and its duration. Taking into account the fact that the pathogenesis of LRP is based on the formation of an inflammatory infiltrate, topical glucocorticosteroids are the drugs of choice for the treatment of LRP in the anogenital area. Conclusion: Genital LRP is a disease associated with a large number of causes and precipitating factors. Numerous studies have shown the efficiency of topical glucocorticosteroid therapy in combination with moisturizing and emollient agents. When properly administered and used, current topical corticosteroids are safe for patients with genital LRP.

diagnosis, symptoms, local therapy, vulva, lichen ruber planus, corticosteroids, combined glucocorticosteroids