Pregnancy complications and outcomes in women with COVID-19


如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

Aim: Analysis of pregnancy complications and outcomes in women with COVID-19. Materials and methods: The retrospective study included 34pregnant women aged 16-40years, who underwent treatment for COVID-19 in hospital. The diagnosis of COVID-19 infection was confirmed by positive PCR test results for SARS-CoV-2 RNA detection in all pregnant women. Results: Most pregnant women (52.9%) had mild symptoms, 20.7% had moderate symptoms and 17.6% had severe symptoms. Pneumonia was diagnosed in 67.1% of pregnant women. Obesity was predominant in the structure of extragenital disorders. It was in 44.1% of women. With COVID-19, iron deficiency anemia (44.2%), preeclampsia (38.2%), risk of preterm birth (35.3%) were predominant in the structure of pregnancy complications. Preterm birth occurred in 36.8% of cases. Cesarean section was performed in 73.3% of cases. The incidence of complications in newborns was 11.6%. 8.8% of newborns were referred to the neonatal intensive care unit. Conclusion: It was found that most pregnant women had mild cases ofCOVID-19. Pregnant women with COVID-19 had high incidence of preeclampsia, preterm birth and cesarean section versus pregnant women without COVID- 19. Intrauterine vertical transmission of infection was not detected. The incidence of complications in newborns was in compliance with general population indicators.

全文:

受限制的访问

作者简介

Yulia Dobrokhotova

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: pr.dobrohotova@mail.ru
Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology, Medical Faculty

Lesya Gumenyuk

V.I. Vernadsky Crimean Federal University

Email: lesya_gymenyuk@mail.ru
Dr. Med. Sci., Professor, Department of Psychiatry, Narcology, and Psychotherapy with a Course of General and Medical Psychology, S.I. Georgievsky Medical Academy

Galina Puchkina

V.I. Vernadsky Crimean Federal University

Email: puchkina.g.a@mail.ru
Assistant of the Department of Obstetrics, Gynecology and Perinatology No. 1, S.I. Georgievsky Medical Academy

Vyacheslav Mikhailichenko

V.I. Vernadsky Crimean Federal University

Email: puchkina.g.a@mail.ru
Professor, Head of the Department of General Surgery, Anesthesiology-Resuscitation and Emergency Medicine, S.I. Georgievsky Medical Academy

参考

  1. Mathad J.S., Gupta A. Pulmonary infections in pregnancy. Semin. Respir. Crit. Care Med. 2017; 38(2): 174-84. https://dx.doi.org/10.1055/s-0037-1602375.
  2. Gregg W.E., Brown A.A. Cognitive and physical disabilities and aging-related complications of diabetes. Clin. Diabetes. 2003; 21(3): 113-8. https://dx.doi.org/10.2337/diaclin.21.3.113.
  3. Westgren M., Pettersson K., Hagberg H., Acharya G. Severe maternal morbidity and mortality associated with COVID-19: The risk should not be down-played. Acta Obstet. Gynecol. Scand. 2020; 99(7): 815-6. https://dx.doi.org/10.1111/aogs.13900.
  4. WHO Q. & A on COVID-19, pregnancy, childbirth and breastfeeding. 18 March 2020. Available at: https://www.who.int/news-room/q-a-detail/q-a-on- covid-19-pregnancychildbirth-and-breastfeeding Accessed April 20 2020.
  5. Royal College of Obstetricians and Gynaecologists. Coronavirus (COVID-19) infectionin pregnancy. Version 8, Published 17 April 2020. Available at: https://www.nih.gov/health-information/coronavirus Accessed April 20 2020.
  6. RANZCOG. A message for pregnant women and their families. Available at: https://ranzcog.edu.au/statementsguidelines/covid-19-statement/information-for-pregnant-women Accessed April 20 2020.
  7. Breslin N., Baptiste C., Gyamfi-Bannerman C., Miller R., Martinez R., Bernstein K. et al. Coronavirus disease 2019 among a symptomatic and symptomatic pregnant women: two weeks of confirmed presentations to an affiliated pair of New York City hospitals. Am. J. Obstet. Gynecol. MFM. 2020; 2(2): 100118. https://dx.doi.org/10.1016/j.ajogmf.2020.100118.
  8. Ковальчук А. С., Кучерявенко А.Н. Течение новой коронавирусной инфекции (COVID-19) у беременной (клинический случай). Журнал инфектологии. 2020; 12(3): 75-9.
  9. Артымук Н.В., Белокриницкая Т.Е., Филиппов О.С., Шифман Е.М. Новая коронавирусная инфекция COVID-19 у беременных Сибири и Дальнего Востока. Вестник интенсивной терапии им. А.И. Салтанова. 2020; 2: 41-8.
  10. Poon L.C., Yang H., Lee J.C.S., Copel J.A., Leung T.Y., Zhang Y. et al. ISUOG Interim Guidance on 2019 novel coronavirus infection during pregnancy and puerperium: information for healthcare professionals. Ultrasound Obstet. Gynecol. 2020; 55(5): 700-8. https://dx.doi.org/10.1002/uog.22013.
  11. Припутневич Т.В., Гордеев А.Б., Любасовская Л.А., Шабанова Н.Е. Новый коронавирус SARS-COV-2 и беременность: обзор литературы. Акушерство и гинекология. 2020; 5: 6-12. [Priputnevich T.V., Gordeev A.B., Lyubasovskaya L.A., Shabanova N.E. The novel coronavirus SARS-CoV-2 and pregnancy: literature review. Obstetrics and Gynecology. 2020; 5: 6-12. (in Russian)]. https://dx.doi.org/10.18565/aig.2020.5.6-12.
  12. Chen H., Guo J., Wang C., Luo F., Yu X., Zhang W. et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospectivere view of medical records. Lancet. 2020; 395(10226): 809-15. https://dx.doi.org/10.1016/S0140-673(20)30360-3.
  13. Артымук Н.В., Белокриницкая Т.Е., Филиппов О.С., Марочко К.В. Особенности течения беременности, акушерская и терапевтическая тактика при новой коронавирусной инфекции COVID-19 у беременных. Акушерство и гинекология. 2020; 12: 6-13. [Artymuk N.V., Belokrinitskaya T.E., Filippov O.S., Marochko K.V. Pregnancy course, obstetric and therapeutic tactics for novel coronavirus infection (COVID-19) in pregnant women. Obstetrics and Gynecology. 2020; 12: 6-13. (in Russian)]. https://dx.doi.org/10.18565/aig.2020.12.6-13.
  14. Припутневич Т. В., Ачкасова Е.Н., Чу баров В. В., Гордеев А. Б. Острые респираторные заболевания и грипп в современном акушерстве: эпидемиологические особенности и проблемы диагностики: обзор литературы. Эпидемиология и вакцинопрофилактика. 2019; 18(3): 89-97. [Priputnevich T.V., Achkasova E.N., Chubarov V.V., Gordeev A.B. Acute Respiratory Diseases and Influenza in Modern Obstetrics: Epidemiological Features and Diagnostic Problems: Literature Review. Epidemiology and Vaccinal Prevention. 2019; 18(3): 89-97. (in Russian)]. https://dx.doi.org/10.31631/2073-3046-201.
  15. Malik A., El Masry K.M., Ravi M., Sayed F. Middle East respiratory syndrome coronavirus during pregnancy. Emerg. Infect. Dis. 2016; 22(3): 515-7. https://dx.doi.org/10.3201/eid2203.151049.
  16. Беженарь В.Ф., Зазерская И.Е., Беттихер О.А., Нестеров И.М., Баутин А.Е. Спорные вопросы акушерской тактики при ведении беременности и родоразрешении пациенток с новой коронавирусной инфекцией COVID-19. Акушерство и гинекология. 2020; 5: 13-21. [Bezhenar V.F.,. Zazerskaya I.E., Bettikher O.A., Nesterov I.M., Bautin A.E. Controversial issues in obstetric management of women with novel coronavirus disease covid-19 during pregnancy and childbirth. Obstetrics and Gynecology. 2020; 5: 13-21. (in Russian)]. https://dx.doi.org/10.18565/aig.2020.5.13-21.
  17. Tam P.C.K., Ly K.M., Kernich M.L., Spurrier N., Lawrence D., Gordon D.L., Tucker E.C. Detectable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human breast milk of a mildly symptomatic patient with coronavirus disease 2019 (COVID-19). Clin. Infect. Dis. 2021; 72(1): 128-30.
  18. Antoun L. Taweel N.E., Ahmed I., Patni S., Honest H. Maternal COVID-19 infection, clinical characteristics, pregnancy, and neonatal outcome: A prospective cohort study. Eur. J. Obstet. Gynecol. Reprod. Biol. 2020; 252: 559-62. https://dx.doi.org/10.1016/j.ejogrb.2020.07.008.
  19. Агеева Л.И., Александрова Г.А., Зайченко Н.М., Кириллова Г.Н., Леонов С.А. Здравоохранение в России. 2019: Стат. сб./Росстат. М.; 2019. 170с.
  20. Vallejo V., Ilagan J.G. A postpartum death due to coronavirus disease 2019 (COVID-19) in the United States. Obstet. Gynecol. 2020; 136(1): 52-5. https://dx.doi.org/10.1097/AOG.0000000000003950.
  21. Lokken E.M., Walker C.L., Delaney S., Kachikis A., Kretzer N.,M., Erickson A. et al. Clinical characteristics of 46 pregnant women with a SARS-CoV-2 infection in Washington State. Am. J. Obstet. Gynecol. 2020; 223(6): 911.e1-911.e14. https://dx.doi.org/10.1016/j.ajog.2020.05.031.
  22. De Jong A., Chanques G., Jaber S. Mechanical ventilation in obese ICU patients: from intubation to extubation. Crit. Care. 2017; 21(1): 63. https://dx.doi.org/10.1186/s13054-017-1641-1.
  23. Ouchi N., Parker J.L., Lugus J.J., Walsh K. Adipokinesin inflammation and metabolic disease. Nat. Rev. Immunol. 2011; 11(2): 85-97.
  24. Hall O.J., Limjunyawong N., Vermillion M.S., Robinson D.P., Wohlgemuth N., Pekosz A. et al. Progesterone-based therapy protects against influenza by promoting lung repair and recovery in females. PLoS Pathog. 2016; 12(9): e1005840.
  25. Pinna G. Sex and COVID-19: a protective role for reproductive steroids. Trends Endocrinol. Metab. 2021; 32(1): 3-6. https://dx.doi.org/10.1016/j.tem.2020.11.004.
  26. Koumoutsea E.V., Vivanti A.J., Shehata N., Benachi A., Le Gouez A., Desconclois C. et al. COVID-19 and acute coagulopathy in pregnancy. J. Thromb. Haemost. 2020; 18(7): 1648-52. https://dx.doi.org/10.1111/jth.14856.
  27. Bao J., Li C., Zhang K., Kang H., Wensen Chen W., Bing Gu B. Comparative analysis of laboratory indexes of severe and non-severe patients infected with COVID-19. Clin. Chim. Acta. 2020; 509: 180-94. https://dx.doi.org/10.1016/j.cca.2020.06.009.
  28. Liu D., Li L., Wu X., Zheng D., Wang D., Yang L., Zheng C. Pregnancy and perinatal outcomes of women with coronavirus disease (COVID-19) pneumonia: a preliminary analysis. AJR. Am. J. Roentgenol. 2020; 215(1): 127-32. https://dx.doi.org/10.2214/AJR.20.23072.
  29. Давыдова, Ю.В., Лиманская А.Ю. Безопасность применения препаратов интерферона в лечении ОРВИ у беременных высокого риска. Перинатология и педиатрия. 2016; 1: 27-32.
  30. Di Mascio D., Khalil A., Saccone G., Rizzo G., Buca D., Liberati M. et al. Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis. Am. J. Obstet. Gynecol. MFM. 2020; 2(2): 100107. https://dx.doi.org/10.1016/j.ajogmf.2020.100107.

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © ООО «Бионика Медиа», 2022
##common.cookie##