PROGNOSTIChESKOE ZNAChENIE ANTITEL K VOZBUDITELYu TUBERKULEZA U DETEY

Abstract


The presence of Mycobacterium tuberculosis antibodies (Ab) is one of the most characteristic signs of tuberculosis. However, the informative value of serodiagnosis is less in children than in adults, in this connection the prognostic value of Ab was determined in children with pulmonary tuberculosis. Eighty-four children with new-onset active pulmonary tuberculosis were followed up. A control group included 25 apparently healthy children from risk groups for tuberculosis. The standard test system EIA-ANTI-TUB® was used to measure the level of Ab. The study was conducted over time: before and 2 and 5 months after initiation of therapy. The sensitivity of the technique was 85.3% and its specificity was 55.1%. The control group showed a direct correlation between the duration and extent of infection and the level of Ab (p < 0.01). The follow-up revealed a correlation between the form of tuberculosis, the severity of its process, and the level of Ab in the children with pulmonary tuberculosis (p < 0.05).

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