The progress in study of results of treatment and prevention of comissures of knee joint


The commissures of knee joint develop after operation or knee trauma at the expense of abnormal proliferation of fibrous tissue provoking limitation of amplitude of motion, arthralgia and joint stiffness. So far, pathogenesis of commissure of knee joint remains unclear. however, there is information that after operation increased secretion of fibroblasts accelerates deposit of extracellular matrix as main mechanism of development of commissures. The application of innovative medical technologies to operate knee joint ameliorated outcomes of treatment and quality of life of patients. However, after surgical operations some patients experience painful sensations and limitation of amplitude of motion of knee joint. The study was targeted to ameliorating of prognosis of operative interventions by means of investigation of pathogenesis of commissure process and possible modes of its prevention.

Full Text

Restricted Access

About the authors

Alexsandr V. Skoroglyadov

The N.I. Pirogov Russian national research medical university Minzdrav of Russia

117997, Moscow, Russian Federation
doctor of medical sciences, professor, head of the chair of traumatology, orthopedics and field military surgery the N.I. Pirogov Russian national research medical university Minzdrav of Russia

U. Haixiao

The N.I. Pirogov Russian national research medical university Minzdrav of Russia

117997, Moscow, Russian Federation

- Chao Zhang

The N.I. Pirogov Russian national research medical university Minzdrav of Russia

117997, Moscow, Russian Federation

E. Kochiay

The N.I. Pirogov Russian national research medical university Minzdrav of Russia

117997, Moscow, Russian Federation

A. V Germanov

The N.I. Pirogov Russian national research medical university Minzdrav of Russia

117997, Moscow, Russian Federation


  1. González Della Valle A., Leali A., Haas S. Etiology and surgical interventions for stiff total knee replacements. HSS J. 2007; 3(2): 182-9.
  2. Fitzsimmons S.E., Vazquez E.A., Bronson M.J. How to treat the stiff total knee arthroplasty?: a systematic review. Clin. Orthop. Relat. Res. 2010; 468(4): 1096-106.
  3. Trudel G., Seki M., Uhthoff H.K. Synovial adhesions are more important than pannus proliferation in the pathogenesis of knee joint contracture after immobilization: an experimental investigation in the rat. J. Rheumatol. 2000; 27(2): 351-7.
  4. Esler C.N., Lock K., Harper W.M., Gregg P.J. Manipulation of total knee replacements. Is the flexion gained retained? J. Bone Joint Surg. Br. 1999; 81(1): 27-9.
  5. Keating E.M., Keating E.M., Ritter M.A., Faris P.M. Manipulation after total knee arthroplasty. J. Bone Joint Surg. Am. 2007; 89(2): 282-6.
  6. Mohammed R., Syed S., Ahmed N. Manipulation under anaesthesia for stiffness following knee arthroplasty. Ann. R. Coll. Surg. Engl. 2009; 91(3): 220-3.
  7. Kim Y.M., Joo Y.B. Prognostic factors of arthroscopic adhesiolysis for arthrofibrosis of the knee. Knee Surg. Relat. Res. 2013; 25(4): 202-6.
  8. Jerosch J., Aldawoudy A.M. Arthroscopic treatment of patients with moderate arthrofibrosis after total knee replacement. Knee Surg. Sports Traumatol. Arthrosc. 2007; 15(1): 71-7.
  9. Pujol N., Boisrenoult P., Beaufils P. Post-traumatic knee stiffness: surgical techniques. Orthop. Traumatol. Surg. Res. 2015; 101(1): 179-86.
  10. Kundu Z., Sangwan S., Guliani G., Siwach R., Kamboj P., Singh R. Thompson's quadricepsplasty for stiff knee. Indian J. Orthop. 2007; 41(4): 390-4.
  11. Hahn S.B., Choi Y.R., Kang H.J., Lee S.H. Prognostic factors and long-term outcomes following a modified Thompson's quadricepsplasty for severely stiff knees. J. Bone Joint Surg. Br. 2010; 92(2): 217-21.
  12. Oliveira V.G. Judet quadricepsplasty in the treatment of posttraumatic knee rigidity: long-term outcomes of 45 cases. J. Trauma Acute Care Surg. 2012; 72(2): 77-80.
  13. Mamarelis G., Sunil-Kumar K.H., Khanduja V. Timing of manipulation under anaesthesia for stiffness after total knee arthroplasty. Ann. Transl. Med. 2015; 3(20): 316.
  14. Joshi R.N., White P.B., Murray-Weir M., Alexiades M.M., Sculco T.P., Ranawat A.S. Prospective Randomized Trial of the Efficacy of Continuous Passive Motion Post Total Knee Arthroplasty: Experience of the Hospital for Special Surgery. J. Arthroplasty. 2015; 30(12): 2364-9.
  15. Tamer T.M. Hyaluronan and synovial joint: function, distribution and healing. Interdiscip. Toxicol. 2013; 6(3): 111-25.
  16. Kanazawa K., Hagiwara Y., Tsuchiya M., Yabe Y., Sonofuchi K., Koide M. Preventing effects of joint contracture by high molecular weight hyaluronan injections in a rat immobilized knee model. Int. J. Clin. Exp. Pathol. 2015; 8(4): 3426-40.
  17. Xu R.S., Hou C.L., Yin C.H., Wang Y.S., Chen A.M. Clinical study on chitosan in prevention of knee adhesion after patellar operation. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2002; 16(4): 240-1.
  18. Sandoval M.A., Hernandez-Vaquero D. Preventing peridural fibrosis with nonsteroidal anti-inflammatory drugs. Eur. Spine J. 2008; 17(3): 451-5.
  19. Breitbach M., Rack D., Dietzel M., Heinz C., Heiligenhaus A. Efficacy of a Dexamethasone Implant for the Treatment of Refractory Cystoid Macular Oedema in Non-Infectious Uveitis. Klin. Monbl. Augenheilkd. 2016; 233(5): 601-5.
  20. Tian F., Dou C., Qi S., Zhao L., Chen B., Yan H. et al. Preventive effect of dexamethasone gelatin sponge on the lumbosacral epidural adhesion. Int. J. Clin. Exp. Med. 2015; 8(4): 5478-84.
  21. Reed K.L., Stucchi A.F., Becker J.M. Pharmacologic inhibition of adhesion formation and peritoneal tissue-type plasminogen activator activity. Semin. Reprod. Med. 2008; 26(4): 331-40.
  22. Arung W., Meurisse M., Detry O. Pathophysiology and prevention of postoperative peritoneal adhesions. World J. Gastroenterol. 2011; 17(41): 4545-53.
  23. Kocaoglu B., Akgun U., Nalbantoglu U., Poyanl O., Karahan M. Adhesion reduction after knee surgery in a rat model by mitomycin C. Knee Surg. Sports Traumatol. Arthrosc. 2011; 19(1): 94-8.
  24. Wang J., Yan L., Sun Y., Wang D., Dai S., Yu T. et al. A comparative study of the preventive effects of mitomycin C and chitosan on intraarticular adhesion after knee surgery in rabbits. Cell Biochem. Biophys. 2012; 62(1): 101-5.
  25. Chang C.C., Wang S.S., Hsieh H.G., Lee W.S., Chuang C.L., Lin H.C. et al. Rosuvastatin improves hepatopulmonary syndrome through inhibition of inflammatory angiogenesis of lung. Clin. Sci. (Lond). 2015; 129(6): 449-60.
  26. Gürer B., Kahveci R., Gökçe E.C., Ozevren H., Turkoglu E., Gökçe A. Evaluation of topical application and systemic administration of rosuvastatin in preventing epidural fibrosis in rats. Spine J. 2015; 15(3): 522-9.



Abstract - 31

PDF (Russian) - 0


Article Metrics

Metrics Loading ...


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies