THE METABOLIC DISORDERS IN MEMBRANE OF ERYTHROCYTES AND INSULIN-BINDING ACTIVITY OF BLOOD CELLS IN PATIENTS UNDER OBESITY AND DIABETES MELLITUS TYPE II

Abstract


The results of clinical metabolic examination of women with diabetes mellitus type II and patients with obesity degree III-IV testify increasing of level of cholesterol, triglycerides, low density lipoproteins and very low density lipoproteins and also coefficient of atherogenity in comparison with control group. These alterations permit to affirm that diabetes mellitus type II in women also as obesity is accompanied by dislipidemia of atherogenic character. At that, in patients with diabetes mellitus type II more intensive alterations of quantitative composition of lipids, including fat acid composition of blood is established. The obesity and diabetes mellitus type II are accompanied by modification of composition of free and esterified fatty acids of blood erythrocytes, increasing of peroxidation of lipids that can result in alteration of functional activity of membranes and in damage of insulin-binding activity of cyto-membranes. The disorder of metabolism of fatty acids accompanied by increasing of concentration of free radicals and decreasing of activity of enzymes of anti-oxidant defense results in decreasing of insulin-binding activity of cells and disorder of processes of glucose utilization.

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About the authors

Nina P. Mikaelyan

The N.I. Pirogov Russian national research medical university Minzdrav of Russia

Email: ninmik@yandex.ru
117997, Moscow, Russian Federation
doctor of biological sciences, professor of the chair of biochemistry and molecular biology of the medical faculty the N.I. Pirogov Russian national research medical university Minzdrav of Russia, 117997, Moscow, Russian Federation

V. V Potemkin

The N.I. Pirogov Russian national research medical university Minzdrav of Russia

117997, Moscow, Russian Federation

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